CAS 362-07-2

2-Methoxyestradiol

Description:

2-Methoxyestradiol (CAS 362-07-2) is a naturally occurring estrogen metabolite derived from estradiol. It is characterized by its methoxy group at the C2 position of the estradiol structure, which influences its biological activity. This compound exhibits a range of pharmacological properties, including anti-angiogenic, anti-inflammatory, and potential anti-cancer effects. It has been studied for its role in inhibiting the proliferation of various cancer cell types and promoting apoptosis. Additionally, 2-Methoxyestradiol has been shown to modulate vascular function and may have implications in cardiovascular health. The substance is typically found in a solid state at room temperature and is soluble in organic solvents. Its mechanism of action involves interaction with estrogen receptors and other molecular targets, contributing to its diverse biological effects. Due to its potential therapeutic applications, 2-Methoxyestradiol has garnered interest in research, particularly in oncology and cardiovascular medicine. However, further studies are needed to fully understand its efficacy and safety in clinical settings.

Formula: C₁₉H₂₆O₃

InChI: InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12?,13-,15?,18+,19+/m1/s1

InChI key: InChIKey=CQOQDQWUFQDJMK-SSTWWWIQSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=C(OC)C4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (17Beta)-2-Methoxyestra-1(10),2,4-Triene-3,17-Diol
• (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
• (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
• (9Xi,14Xi,17Beta)-2-Methoxyestra-1(10),2,4-Triene-3,17-Diol
• 2-Hydroxyestradiol 2-methyl ether
• 2-Hydroxyestradol 2-methyl ether
• 2-Methoxy-E2
• 2-Methoxyestra-1(10),2,4-Triene-3,17-Diol
• 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol
• 2-Methoxyestra-1,3,5(10)-triene-3,17β-diol
• 2-Methoxyestradiol-17beta
• 2Me2
• Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17beta)-
• Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-
• Estra-1,3,5(10)-triene-3,17beta-diol, 2-methoxy-
• Estra-1,3,5(10)-triene-3,17β-diol, 2-methoxy-
• Estradiol, 2-methoxy-
• Nsc 659853
• Panzem
• Unii-6I2Qw73Sr5
• 2-Methoxyestradiol
• 2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• 3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE
• 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER
• 2-Methoxy-17b-estradiol
• 2-METHOXYOESTRADIOL
• 2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS
• 2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
• 2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
• 1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER
• 1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER
• 2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE
• 2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL
• 2-METHOXYESTRADIOL 98+%

2-Methoxy-β-estradiol

CAS: 362-07-2

Formula: C₁₉H₂₆O₃

Purity: >97.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 302.41

Ref: 3B-M2530

(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

CAS: 362-07-2

Formula: C₁₉H₂₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 302.4079

Ref: IN-DA0037YB

2-Methoxyestradiol

CAS: 362-07-2

2-Methoxyestradiol

Purity: 98%

Molecular weight: 302.41g/mol

Ref: 54-OR1025732

2-Methoxyestradiol

CAS: 362-07-2

2-Methoxyestradiol

Purity: ≥98%

Molecular weight: 302.41g/mol

Ref: 54-BUP14634

2-Methoxyestradiol

CAS: 362-07-2

Formula: C₁₉H₂₆O₃

Purity: ≥ 98.0%

Color and Shape: White to faint yellow powder or crystals

Molecular weight: 302.41

Ref: 7W-GP7140

2-Methoxyestradiol

Controlled Product

CAS: 362-07-2

Formula: C₁₉H₂₆O₃

Color and Shape: Neat

Molecular weight: 302.41

Ref: 86-MM0300.18

2-Methoxyestradiol

CAS: 362-07-2

2-ME2, an estradiol derivative, hinders angiogenesis and tumor growth, causes cell apoptosis, and stops mitosis.

Formula: C₁₉H₂₆O₃

Purity: 98% - 99.95%

Color and Shape: Off-White Solid

Molecular weight: 302.41

Ref: TM-T2220

2-Methoxy 17β-Estradiol

Controlled Product

CAS: 362-07-2

Applications 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995), D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1994), Forsis, T., et al.: Nature, 368, 237 (1994)

Formula: C₁₉H₂₆O₃

Color and Shape: Off White

Molecular weight: 302.41

Ref: TR-M262625

2-Methoxy 17b-estradiol

Controlled Product

CAS: 362-07-2

2-Methoxy 17b-estradiol is a synthetic estrogen that binds to DNA and alters the transcriptional process. It has been shown to induce apoptosis by activating the pro-apoptotic protein Bax and inhibiting the anti-apoptotic protein Bcl-2. This drug inhibits the metabolic response of cancer cells to chemotherapy, leading to a decrease in tumor size, and can be used as an implantable device for treating cancer. 2-Methoxy 17b-estradiol also has minimal toxicity in comparison to other estrogens, with no significant cytotoxicity observed in cells of reproductive tissues or endocrine organs, nor any significant toxic effects on liver function tests or serum lipids.

Formula: C₁₉H₂₆O₃

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 302.41 g/mol

Ref: 3D-FM25168

2-Methoxy 17β-Estradiol

CAS: 362-07-2

Formula: C₁₉H₂₆O₃

Molecular weight: 302.4

Ref: ST-EA-CP-E61022