CAS 362-08-3

2-Methoxyestrone

Description:

2-Methoxyestrone, with the CAS number 362-08-3, is a synthetic derivative of estrone, a naturally occurring estrogen. It is characterized by the presence of a methoxy group (-OCH3) at the second carbon position of the estrone structure, which influences its biological activity and solubility. This compound typically appears as a white to off-white crystalline powder and is soluble in organic solvents such as ethanol and methanol, but has limited solubility in water. 2-Methoxyestrone exhibits estrogenic activity, which means it can bind to estrogen receptors and may influence various physiological processes, including reproductive functions and bone density. It is often studied for its potential therapeutic applications in hormone replacement therapy and its role in cancer research, particularly in relation to breast cancer. As with many steroid derivatives, it is important to handle 2-Methoxyestrone with care, following appropriate safety protocols due to its biological activity.

Formula: C₁₉H₂₄O₃

InChI: InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1

InChI key: InChIKey=WHEUWNKSCXYKBU-QPWUGHHJSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=C(OC)C4)(CC1)[H])[H])(CCC2=O)[H]

Synonyms:

• 2-Hydroxyestrone 2-methyl ether
• 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol
• 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one
• 3-Hydroxy-2-Methoxyestra-1(10),2,4-Trien-17-One
• 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
• Estra-1,3,5(10)-trien-17-one, 3-hydroxy-2-methoxy-
• Estrone, 2-methoxy-
• Gss 33
• 2-Methoxyestrone

2-Methoxyestrone

CAS: 362-08-3

2-Methoxyestrone

Purity: ≥95%

Molecular weight: 300.39g/mol

Ref: 54-BUP21091

2-Methoxy Estrone

Controlled Product

CAS: 362-08-3

Applications 2-Methoxyestrone is a endogenous estrogen metabolite. 2-Methoxyestrone detection can be used as a breast cancer biomarker and help assess the risk-factors for development of breast cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Franke, A.A. et al.: Ana;. Bioanal. Chem., 401, 1319 (2011); Farlow, D.W. et al.: J. Chrom B Anal. Technol. Biomed Life Sci., 877, 1327 (2009);

Formula: C₁₉H₂₄O₃

Color and Shape: Neat

Molecular weight: 300.39

Ref: TR-M262520

2-Methoxy Estrone

CAS: 362-08-3

Formula: C₁₉H₂₄O₃

Molecular weight: 300.4

Ref: ST-EA-CP-E30001

2-Methoxy estrone

Controlled Product

CAS: 362-08-3

2-Methoxy estrone is a metabolite of estrone and is produced by the enzyme 2-hydroxylase. This compound has minimal toxicity and can be used as a marker for biological processes, such as cellular transformation. 2-Methoxy estrone has been shown to inhibit the activity of acetylcholinesterase, an enzyme that breaks down acetylcholine, which is essential for neurotransmission. It has also been implicated in the regulation of angiogenic processes in vitro and in vivo. The role of 2-methoxy estrone in cancer cells is not fully understood but it may have potential as a biomarker for prostate cancer and breast cancer.

Formula: C₁₉H₂₄O₃

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 300.39 g/mol

Ref: 3D-FM25178

2-Methoxyestrone

CAS: 362-08-3

2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone, a nonuterotropic metabolite of estradiol.

Formula: C₁₉H₂₄O₃

Purity: 97.07% - 99.18%

Color and Shape: Solid

Molecular weight: 300.39

Ref: TM-T13481