CAS 362-29-8

(±)-Propiomazine

Description:

(±)-Propiomazine is a phenothiazine derivative primarily used as an antipsychotic and sedative medication. It exhibits a range of pharmacological properties, including antihistaminic, anticholinergic, and antiemetic effects. The substance is characterized by its ability to block dopamine receptors in the central nervous system, which contributes to its therapeutic effects in managing anxiety and agitation. (±)-Propiomazine is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The compound is known for its sedative properties, making it useful in preoperative settings and for treating insomnia. Its chemical structure includes a thiazine ring, which is common among phenothiazine derivatives, and it possesses a chiral center, resulting in a racemic mixture of enantiomers. Side effects may include sedation, dry mouth, and potential extrapyramidal symptoms, necessitating careful monitoring during use. Overall, (±)-Propiomazine is a valuable agent in psychiatric and medical practice, though its use must be balanced with awareness of its side effects and contraindications.

Formula: C₂₀H₂₄N₂OS

InChI: InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3

InChI key: InChIKey=UVOIBTBFPOZKGP-UHFFFAOYSA-N

SMILES: C(C(N(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(C(CC)=O)C2

Synonyms:

• 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
• 1-Propanone, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-
• 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone
• 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone
• 10-(2-Dimethylaminopropyl)Phenothiazin-2-Yl Ethyl Ketone
• 2-Acetyl-10-(3-Dimethylamino-2-Methylpropyl)Phenothiazine
• 2-Propionyl-10-[2-(dimethylamino)propyl]phenothiazine
• Propiomazin
• Propiomazina
• Propionylpromethazine
• Wy 1359
• Propiomazine
• CB-1678
• propiomazine USP/EP/BP
• 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

Propiomazine

CAS: 362-29-8

Propiomazine

Purity: ≥98%

Molecular weight: 340.48g/mol

Ref: 54-BUP21177

Propiomazine

CAS: 362-29-8

Formula: C₂₀H₂₄N₂OS

Molecular weight: 340.49

Ref: 4Z-P-159002

1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone (>90%)

Controlled Product

CAS: 362-29-8

Applications 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.
References Loevheim, H. et al.: Pharmacoepidemiol. Drug Safety, 17, 912 (2008);

Formula: C₂₀H₂₄N₂OS

Color and Shape: Neat

Molecular weight: 340.48

Ref: TR-D471065

1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone-d6

Controlled Product

CAS: 362-29-8

Formula: C₂₀D₆H₁₈N₂OS

Color and Shape: Neat

Molecular weight: 346.519

Ref: TR-D471067

Propiomazine

CAS: 362-29-8

Propiomazine is an orally active antihistamine compound with sedative properties, useful for controlling insomnia in neurological disorders.

Formula: C₂₀H₂₄N₂OS

Purity: 98.5%

Color and Shape: Solid

Molecular weight: 340.48

Ref: TM-T61088