CAS 362665-56-3

Pitolisant

Description:

Pitolisant, with the CAS number 362665-56-3, is a novel medication primarily used for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy. It functions as a selective histamine H3 receptor antagonist/inverse agonist, which enhances the release of histamine in the brain, promoting wakefulness and alertness. Pitolisant is known for its favorable side effect profile compared to traditional stimulants, as it does not exhibit the same potential for abuse or dependency. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a pyridine ring, contributing to its pharmacological activity. Pitolisant has been shown to improve both subjective and objective measures of wakefulness in clinical studies, making it a significant advancement in the management of narcolepsy. As with any medication, it is essential to consider potential interactions and contraindications when prescribing or using Pitolisant.

Formula: C₁₇H₂₆ClNO

InChI: InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2

InChI key: InChIKey=NNACHAUCXXVJSP-UHFFFAOYSA-N

SMILES: C(CCOCCCN1CCCCC1)C2=CC=C(Cl)C=C2

Synonyms:

• 3-(4-Chlorophenyl)propyl 3-piperidinopropyl ether
• Wakix
• Pitolisant
• 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]piperidine
• Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-

Pitolisant (BF2.649)

CAS: 362665-56-3

Formula: C₁₇H₂₆ClNO

Purity: 95%

Color and Shape: Liquid

Molecular weight: 295.8474

Ref: IN-DA003TT4

Pitolisant

CAS: 362665-56-3

Pitolisant

Purity: ≥98%

Molecular weight: 295.85g/mol

Ref: 54-BUP10262

Pitolisant

Controlled Product

CAS: 362665-56-3

Formula: C₁₇H₂₆ClNO

Color and Shape: Neat

Molecular weight: 295.847

Ref: TR-P536505

Pitolisant

CAS: 362665-56-3

Pitolisant is a selective histamine H3 receptor inverse agonist, originating from chemical research into histaminergic pathways. It works by binding to histamine H3 receptors in the brain, functioning primarily as an antagonist/inverse agonist. This action leads to increased release of neurotransmitters such as histamine, acetylcholine, and norepinephrine, which play crucial roles in wakefulness and attention.

Formula: C₁₇H₂₆ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 295.85 g/mol

Ref: 3D-FP168175

PITOLISANT

CAS: 362665-56-3

Purity: 98%

Molecular weight: 295.8500061

Ref: 10-F813261

Pitolisant

CAS: 362665-56-3

Pitolisant is a potent and selective nonimidazole inverse agonist that acts on the recombinant human histamine H3 receptor with Ki of 0.16 nM.

Formula: C₁₇H₂₆ClNO

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 295.85

Ref: TM-T60636