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CAS 36357-77-4

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Phosphoramidon

Description:
Phosphoramidon is a synthetic compound classified as a phosphoramidate and is primarily known for its role as a potent inhibitor of metalloproteinases, particularly matrix metalloproteinases (MMPs). It is characterized by its ability to interfere with the enzymatic activity of these proteins, which are involved in the degradation of extracellular matrix components. This inhibition has implications in various biological processes, including tissue remodeling and inflammation. Phosphoramidon is often utilized in research settings to study the role of MMPs in disease states such as cancer and arthritis. The compound is typically presented as a white to off-white solid and is soluble in organic solvents. Its mechanism of action involves binding to the active site of MMPs, thereby preventing substrate access and subsequent enzymatic activity. Due to its specific inhibitory properties, phosphoramidon serves as a valuable tool in pharmacological studies aimed at understanding and potentially treating conditions associated with abnormal MMP activity. Safety and handling precautions are necessary, as with many chemical substances, to mitigate any potential health risks.
Formula:C23H34N3O10P
InChI:InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1
InChI key:InChIKey=ZPHBZEQOLSRPAK-XLCYBJAPSA-N
SMILES:C([C@H](NC([C@@H](NP(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)(=O)O)CC(C)C)=O)C(O)=O)C=2C=3C(NC2)=CC=CC3
Synonyms:
  • (2S)-2-({(2S)-2-[(hydroxy{[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}phosphoryl)amino]-4-methylpentanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name)
  • L-Tryptophan, N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-
  • (2S)-2-({(2R)-2-[(hydroxy{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}phosphoryl)amino]-4-methylpentanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name)
  • L-Tryptophan, N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-
  • N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-L-tryptophan
  • Phosphoramidon
  • (2S)-2-({(2S)-2-[(hydroxy{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}phosphoryl)amino]-4-methylpentanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name)
  • N-(N-(((6-Deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-L-tryptophan
  • L-Tryptophan, N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-
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Found 2 products.
  • Phosphoramidon
    Targetmol
    + Info

    Phosphoramidon

    CAS:
    Phosphoramidon inhibits metallo-endopeptidase, endothelin-converting enzyme, and thermolysin; derived from Streptomyces tanashiensis culture.
    Formula:C23H34N3O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.5

    Ref: TM-T20541

  • Phosphoramidon
    Biosynth
    + Info

    Phosphoramidon

    CAS:
    <p>Phosphoramidon is a peptide that is used as a research tool. It has been shown to activate the protein kinase C, which plays a role in the regulation of ion channels and other cellular functions. Phosphoramidon binds to the receptor site of protein A and inhibits the binding of phosphorylated erythropoietin (EPO) to its receptor. EPO is an important hormone for red blood cell production.</p>
    Formula:C23H34N3O10P
    Purity:Min. 95%
    Molecular weight:543.50 g/mol

    Ref: 3D-IPO-4082-V

    500µg
    262.00€