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CAS 364613-34-3

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N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite

Description:
N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a synthetic nucleoside derivative used primarily in the field of oligonucleotide synthesis. This compound features a deoxycytidine base, which is a component of DNA, modified with an N-acetyl group and a 5'-dimethoxytrityl (DMT) protecting group that facilitates the attachment of nucleotides during synthesis. The presence of the bis(acetyloxy)ethyl moiety enhances solubility and stability, making it suitable for various biochemical applications. The phosphoramidite functional group allows for the incorporation of this compound into growing oligonucleotide chains through phosphite triester chemistry. This substance is typically utilized in the synthesis of modified oligonucleotides for research, therapeutic, and diagnostic purposes, particularly in the development of antisense oligonucleotides and RNA interference technologies. Its unique structural features contribute to its reactivity and compatibility with standard oligonucleotide synthesis protocols.
Formula:C47H58N5O12P
Synonyms:
  • N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite
  • Cytidine, N-acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
  • 5'-Dimethoxytrityl-N-acetyl-5-(1,2-diacetyloxy-ethyl)-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
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  • N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite
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    N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite

    CAS:
    <p>N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a Ribonucleoside, Deoxyribonucleoside, Activator, Antiviral. It is a modified nucleoside with N-(acetyl)-N′-[1,2-bis(acetyloxy)ethyl]glycine esterified to the 5′ position of the ribose and 2′deoxycytidine esterified to the 3′ position of the sugar. <br>N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite has been shown to inhibit HIV replication in vitro and in vivo. This drug also inhibits influenza A viruses and herpes simplex virus type 1 (</p>
    Formula:C47H58N5O12P
    Purity:Min. 95%
    Molecular weight:915.96 g/mol

    Ref: 3D-PA146815

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