CAS 36508-71-1: Zorubicin hydrochloride

Description: Zorubicin hydrochloride is an anthracycline antibiotic and chemotherapeutic agent primarily used in the treatment of various cancers, particularly in hematological malignancies. It is a derivative of doxorubicin and exhibits potent antitumor activity by intercalating into DNA, thereby inhibiting DNA and RNA synthesis, which ultimately leads to cell death. The compound is characterized by its ability to generate free radicals, contributing to its cytotoxic effects. Zorubicin hydrochloride is typically administered intravenously and is known for its potential side effects, including cardiotoxicity, myelosuppression, and gastrointestinal disturbances. Its chemical structure includes a sugar moiety, which enhances its solubility and bioavailability. The hydrochloride form indicates that it is a salt, which can improve stability and facilitate formulation. As with other anthracyclines, careful monitoring of cardiac function is essential during treatment due to the risk of cumulative dose-related cardiotoxicity. Overall, Zorubicin hydrochloride represents a critical option in the oncological pharmacotherapy arsenal, particularly for patients with specific cancer types.

Formula: C₃₄H₃₅N₃O₁₀·ClH

InChI: InChI=1S/C34H35N3O10.ClH/c1-15-28(38)20(35)12-23(46-15)47-22-14-34(44,16(2)36-37-33(43)17-8-5-4-6-9-17)13-19-25(22)32(42)27-26(30(19)40)29(39)18-10-7-11-21(45-3)24(18)31(27)41;/h4-11,15,20,22-23,28,38,40,42,44H,12-14,35H2,1-3H3,(H,37,43);1H/t15-,20-,22-,23-,28+,34-;/m0./s1

InChI key: InChIKey=NKFHKYQGZDAKMX-QMFNWPJUSA-N

SMILES: Cl.O=C(NN=C(C)C1(O)CC2=C(O)C=3C(=O)C=4C=CC=C(OC)C4C(=O)C3C(O)=C2C(OC5OC(C)C(O)C(N)C5)C1)C=6C=CC=CC6

Synonyms:

• Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, hydrochloride (1:1)
• Benzoic acid, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride
• Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)-
• N'-[(1E)-1-{(2S,4S)-4-[(3-amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl}ethylidene]benzohydrazide
• N'-[(1E)-1-{4-[(3-amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl}ethylidene]benzohydrazide
• NSC 164011
• RP 22050 hydrochloride
• Rubidazone hydrochloride
• Zorubicin hydrochloride
• Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, hydrochloride (1:1)
• Benzoic acid, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride
• Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)-

Zorubicin hydrochloride

CAS: 36508-71-1

• Formula: C₃₄H₃₆ClN₃O₁₀
• Molecular weight: 682.12

Zorubicin HCl

CAS: 36508-71-1

• Formula: C₃₄H₃₅N₃O₁₀·HCl
• Molecular weight: 645.67 36.46

Zorubicin hydrochloride

CAS: 36508-71-1

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• Formula: C₃₄H₃₆ClN₃O₁₀
• Purity: Min. 95%
• Color and Shape: Red Powder
• Molecular weight: 682.12 g/mol