CAS 365462-23-3

Darexaban

Description:

Darexaban is an anticoagulant medication that belongs to the class of direct factor Xa inhibitors. It is primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. The chemical structure of darexaban features a unique bicyclic core that contributes to its pharmacological activity. It exhibits high selectivity for factor Xa, which is crucial in the coagulation cascade, thereby inhibiting thrombin generation and preventing clot formation. Darexaban is characterized by its oral bioavailability, allowing for convenient administration. Its pharmacokinetics include a relatively short half-life, necessitating careful consideration of dosing regimens. The substance is also subject to metabolic processes primarily involving hepatic enzymes, which can influence its efficacy and safety profile. As with other anticoagulants, monitoring for potential bleeding complications is essential during treatment. Overall, darexaban represents a significant advancement in anticoagulant therapy, offering a targeted approach to managing thrombotic conditions.

Formula: C₂₇H₃₀N₄O₄

InChI: InChI=1S/C27H30N4O4/c1-30-15-4-16-31(18-17-30)21-11-7-19(8-12-21)27(34)29-25-23(5-3-6-24(25)32)28-26(33)20-9-13-22(35-2)14-10-20/h3,5-14,32H,4,15-18H2,1-2H3,(H,28,33)(H,29,34)

InChI key: InChIKey=IJNIQYINMSGIPS-UHFFFAOYSA-N

SMILES: N(C(=O)C1=CC=C(C=C1)N2CCCN(C)CC2)C3=C(NC(=O)C4=CC=C(OC)C=C4)C=CC=C3O

Synonyms:

• Darexaban
• Benzamide, N-[2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxyphenyl]-4-methoxy-
• N-[2-[[4-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxyphenyl]-4-methoxybenzamide

N-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide

CAS: 365462-23-3

Formula: C₂₇H₃₀N₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 474.5515

Ref: IN-DA00CN0H

Darexaban

CAS: 365462-23-3

Darexaban

Purity: ≥98%

Molecular weight: 474.55g/mol

Ref: 54-BUP08125

N-(3-Hydroxy-2-(4-(4-Methyl-1,4-Diazepan-1-Yl)Benzamido)Phenyl)-4-Methoxybenzamide

CAS: 365462-23-3

N-(3-Hydroxy-2-(4-(4-Methyl-1,4-Diazepan-1-Yl)Benzamido)Phenyl)-4-Methoxybenzamide

Purity: 97%

Molecular weight: 474.55g/mol

Ref: 54-OR1024168

Darexaban

CAS: 365462-23-3

Darexaban (YM-150) selectively inhibits Factor Xa, reducing clotting and risk of heart/stroke events.

Formula: C₂₇H₃₀N₄O₄

Purity: 98.33%

Color and Shape: Solid

Molecular weight: 474.55

Ref: TM-T31206

Darexaban

CAS: 365462-23-3

Darexaban is a non-peptidic, small molecule that inhibits the enzyme glucuronide conjugate. It is used to prevent and treat thrombosis and thromboembolism in patients undergoing atrial or abdominal surgery. Darexaban has been shown to be effective in the treatment of heparin-induced thrombocytopenia (HIT) by inhibiting the activation of platelets. The drug also has pharmacokinetic properties that are similar to those of heparin, such as a half-life of 5–7 hours. Darexaban also has anti-inflammatory effects, and can reduce autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.

Purity: Min. 95%

Ref: 3D-FD36340