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CAS 366017-09-6

:

Mubritinib

Description:
Mubritinib, with the CAS number 366017-09-6, is a small molecule inhibitor primarily targeting the Bruton's tyrosine kinase (BTK), which plays a crucial role in B-cell receptor signaling. This compound is classified as a kinase inhibitor and is particularly relevant in the treatment of certain hematological malignancies, including B-cell malignancies. Mubritinib exhibits selectivity for BTK, which is essential for its therapeutic efficacy, as it minimizes off-target effects that can lead to adverse reactions. The substance is typically administered orally and has been investigated in clinical trials for its potential to improve outcomes in patients with specific types of cancer. Its mechanism of action involves the inhibition of BTK, leading to the disruption of signaling pathways that promote cell proliferation and survival in malignant B-cells. As with many targeted therapies, the pharmacokinetics, safety profile, and efficacy of Mubritinib are subjects of ongoing research to optimize its use in clinical settings.
Formula:C25H23F3N4O2
InChI:InChI=1/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChI key:InChIKey=ZTFBIUXIQYRUNT-MDWZMJQESA-N
SMILES:C(=C/C1=CC=C(C(F)(F)F)C=C1)\C2=NC(COC3=CC=C(CCCCN4C=CN=N4)C=C3)=CO2
Synonyms:
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • 1-(4-{4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole
  • 1H-1,2,3-Triazole, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-
  • Tak 165
  • Mubritinib
  • Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • Mubritinib(TAK 165)
  • TAK165;TAK-165
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165)
  • CS-522
  • See more synonyms
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