CAS 36622-28-3

(-)-Verapamil hydrochloride

Description:

(-)-Verapamil hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension, angina, and certain arrhythmias. It is a chiral compound, with the "(-)" indicating its specific stereoisomer, which is biologically active. The substance is typically presented as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. Its mechanism of action involves inhibiting the influx of calcium ions through L-type calcium channels in cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. This compound also exhibits antiarrhythmic properties, making it effective in managing certain types of cardiac dysrhythmias. In addition to its cardiovascular applications, (-)-Verapamil has been studied for its potential effects on migraine prophylaxis and cluster headaches. As with any medication, it is essential to consider its pharmacokinetics, potential side effects, and interactions with other drugs when prescribing or using it in clinical settings.

Formula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m0./s1

InChI key: InChIKey=DOQPXTMNIUCOSY-YCBFMBTMSA-N

SMILES: [C@@](CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Synonyms:

• LU 33926
• (-)-Verapamil hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (αS)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1), (αS)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (S)-

S-(-)-Verapamil hydrochloride hydrate

CAS: 36622-28-3

Ref: 7W-GP2507

S-Verapamil HCl

CAS: 36622-28-3

Formula: C₂₇H₃₈N₂O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 454.61 36.46

Ref: 4Z-V-044

(S)-(-)-Verapamil Hydrochloride

CAS: 36622-28-3

Applications Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988), Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990),

Formula: C₂₇H₃₈N₂O₄·ClH

Color and Shape: Neat

Molecular weight: 491.06

Ref: TR-V124991

(S)-Verapamil hydrochloride

CAS: 36622-28-3

(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.

Formula: C₂₇H₃₉ClN₂O₄

Color and Shape: Solid

Molecular weight: 491.06

Ref: TM-T13879