CAS 367-21-5

3-Chloro-4-fluoroaniline

Description:

3-Chloro-4-fluoroaniline is an aromatic amine characterized by the presence of both chlorine and fluorine substituents on a benzene ring. Specifically, the chlorine atom is located at the meta position (3-position) and the fluorine atom at the para position (4-position) relative to the amino group (-NH2). This compound is typically a solid at room temperature and may exhibit a pale yellow to light brown color. It is known for its moderate solubility in organic solvents and limited solubility in water, which is common for many substituted anilines. The presence of electronegative halogens influences its reactivity, making it a useful intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Additionally, 3-chloro-4-fluoroaniline may exhibit specific biological activities, which can be of interest in medicinal chemistry. Safety precautions should be taken when handling this compound, as it may pose health risks, including skin and respiratory irritation. Proper storage and disposal methods are essential to mitigate environmental impact.

Formula: C₆H₅ClFN

InChI: InChI=1S/C6H5ClFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2

InChI key: InChIKey=YSEMCVGMNUUNRK-UHFFFAOYSA-N

SMILES: ClC1=C(F)C=CC(N)=C1

Synonyms:

• 3-Chloro-4-Fluoro Aniline
• 3-Chloro-4-Fluorobenzenamine
• 3-Chloro-4-fluorophenylamine
• 4-Fluoro-3-chloroaniline
• Aniline, 3-chloro-4-fluoro-
• Benzenamine, 3-chloro-4-fluoro-
• NSC 10290
• m-Chloro-p-fluoroaniline
• 3-Chloro-4-fluoroaniline

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Formula: C₆H₅ClFN

Purity: >98.0%(GC)

Color and Shape: Gray to Dark purple to Black powder to lump

Molecular weight: 145.56

Ref: 3B-C1024

3-Chloro-4-fluoroaniline, 98%

CAS: 367-21-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: White to brown to dark brown or purple, Crystals or powder or crystalline powder or fused/lumpy solid

Molecular weight: 145.56

Ref: 02-A11858

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: Solid

Molecular weight: 145.5620

Ref: IN-DA0033NL

3-Chloro-4-fluoroaniline

CAS: 367-21-5

3-Chloro-4-fluoroaniline

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: white to faint grey crystalline with dark purple solid inside crystalline solid

Molecular weight: 145.562g/mol

Ref: 54-PC1820

Gefitinib Impurity 58

CAS: 367-21-5

Formula: C₆H₅ClFN

Color and Shape: White To Off-White Solid

Molecular weight: 145.56

Ref: 4Z-G-2314

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Formula: C₆H₅ClFN

Purity: ≥ 98.5%

Color and Shape: Colourless, off-white or beige crystals

Molecular weight: 145.56

Ref: 7W-GK9936

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: Solid

Molecular weight: 145.56

Ref: 10-F001682

3-Chloro-4-fluoroaniline

Controlled Product

CAS: 367-21-5

Formula: C₆H₅ClFN

Color and Shape: Neat

Molecular weight: 145.56

Ref: 04-C11415200

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Color and Shape: Neat

Ref: 86-MM3563.04

4-Fluoro-3-chloroaniline

Controlled Product

CAS: 367-21-5

Applications 4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reddy, D. R. S., et al.: Pharma Chemica., 5, 207 (2013);

Formula: C₆H₅ClFN

Color and Shape: Neat

Molecular weight: 145.56

Ref: TR-F589015

3-Chloro-4-fluoroaniline

CAS: 367-21-5

3-Chloro-4-fluoroaniline is a versatile building block that can be used in the synthesis of many different compounds. It is a reagent that is used in research, where it can be used as a reactant or an intermediate. This chemical has been shown to have high quality and can be used as a starting material for the synthesis of other chemicals. 3-Chloro-4-fluoroaniline has been shown to react with various functional groups such as amines and acid chlorides. It is also useful for the construction of scaffolds, which are three dimensional structures that are built from small molecules and organic compounds. 3-Chloro-4-fluoroaniline is classified as a speciality chemical and its CAS number is 367-21-5.

Formula: C₆H₅ClFN

Molecular weight: 145.56 g/mol

Ref: 3D-C-3925

3-Chloro-4-fluoroaniline

CAS: 367-21-5

Formula: C₆H₅ClFN

Molecular weight: 145.56

Ref: ST-EA-CP-G14014

3-Chloro-4-fluoroaniline

CAS: 367-21-5

3-Chloro-4-fluoroaniline is an amine that is used as a chemical intermediate and an antimicrobial agent. It is a potent inhibitor of the enzyme IDO1. 3-Chloro-4-fluoroaniline has been shown to inhibit the growth of carcinoma cell lines and epidermal growth factor in vitro, which may be due to its ability to inhibit the production of protein data. This drug also inhibits the production of the growth factor n-dimethyl formamide by hydrolyzing it into dimethylamine and formic acid, which are then excreted in urine samples. 3-Chloro-4-fluoroaniline has been found to be highly effective at inhibiting IDO1, as well as other enzymes such as tryptophan 2,3 dioxygenase (TDO2) and indoleamine 2,3 dioxygenase (IDO).

Formula: C₆H₅ClFN

Purity: Min. 95%

Color and Shape: Clear Liquid Solidified Mass

Molecular weight: 145.56 g/mol

Ref: 3D-FC34831

3-Chloro-4-Fluoroaniline pure, 98%

CAS: 367-21-5

Formula: C₆H₅ClFN

Purity: min. 98%

Color and Shape: Light yellow to grayish to light purple, Crystals or Crystalline Chunk or Solid or Granules, Clear

Molecular weight: 145.57

Ref: SR-10455