CAS 367-22-6

4-Chloro-3-fluorobenzenamine

Description:

4-Chloro-3-fluorobenzenamine, also known as 3-Fluoro-4-chloroaniline, is an aromatic amine characterized by the presence of both a chloro and a fluoro substituent on a benzene ring. The compound features a primary amine functional group (-NH2) attached to the benzene, which influences its reactivity and solubility. It typically appears as a solid at room temperature and is soluble in organic solvents, with limited solubility in water due to its hydrophobic aromatic structure. The presence of the electronegative chlorine and fluorine atoms can affect the compound's electronic properties, making it a useful intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Additionally, 4-Chloro-3-fluorobenzenamine may exhibit biological activity, which can be explored in various chemical and medicinal applications. Safety precautions should be taken when handling this compound, as it may pose health risks, including skin and respiratory irritation. Proper storage and disposal methods are essential to mitigate environmental impact.

Formula: C₆H₅ClFN

InChI: InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2

InChI key: InChIKey=ACMJJQYSPUPMPN-UHFFFAOYSA-N

SMILES: FC1=C(Cl)C=CC(N)=C1

Synonyms:

• 3-Fluoro-4-Chloroaniline
• 3-Fluoro-4-chlorobenzenamine
• 4-Chloro-3-fluorobenzenamine
• 4-Chloro-3-fluorobenzeneamine
• 4-Chloro-3-fluorophenylamine
• Aniline, 4-chloro-3-fluoro-
• Benzenamine, 4-chloro-3-fluoro-
• 4-Chloro-3-fluoroaniline

4-Chloro-3-fluoroaniline

CAS: 367-22-6

Formula: C₆H₅ClFN

Purity: >97.0%(GC)(T)

Color and Shape: White to Gray to Red powder to crystal

Molecular weight: 145.56

Ref: 3B-C2512

4-Chloro-3-fluoroaniline, 99%

CAS: 367-22-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₅ClFN

Purity: 99%

Color and Shape: White to pale cream or grey, Crystals or powder or crystalline powder or lumpy/fused solid

Molecular weight: 145.56

Ref: 02-H26148

4-Chloro-3-Fluoroaniline

CAS: 367-22-6

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: Solid

Molecular weight: 145.5620

Ref: IN-DA003L4M

4-Chloro-3-fluoroaniline

CAS: 367-22-6

4-Chloro-3-fluoroaniline

Formula: C₆H₅ClFN

Purity: 98%

Color and Shape: off-white to gray solid

Molecular weight: 145.562g/mol

Ref: 54-PC0361

4-Chloro-3-fluoroaniline

CAS: 367-22-6

Formula: C₆H₅ClFN

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 145.56

Ref: 10-F009745

4-Chloro-3-fluoroaniline

CAS: 367-22-6

4-Chloro-3-fluoroaniline is a synthetic compound with a molecular formula of C6H4ClFNO. It is an epoxide hydrolase inhibitor and has been shown to produce a frequency shift in the infrared spectrum. This compound also has an additive reaction yield and produces hydrogen fluoride when reacted with hydrochloric acid. 4-Chloro-3-fluoroaniline has two isomers, one that is fluorescent and the other that is not. The reaction product of the two isomers can be determined by mass spectrometry analysis. The dipole moment of this compound can be detected by fluorescence spectroscopy.

Formula: C₆H₅ClFN

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 145.56 g/mol

Ref: 3D-FC34022

4-Chloro-3-fluoroaniline

Controlled Product

CAS: 367-22-6

Applications 4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib (G304000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mayes, B.A., et al.: Org. Process Res. Dev., 14, 1248 (2010); Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)

Formula: C₆H₅ClFN

Color and Shape: Neat

Molecular weight: 145.56

Ref: TR-C367100