CAS 367514-87-2

Lurasidone

Description:

Lurasidone is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and bipolar disorder. It functions as a dopamine D2 receptor antagonist and a serotonin 5-HT2A receptor antagonist, which contributes to its therapeutic effects. The chemical formula of Lurasidone is C24H25ClN2O2S, and it features a thienobenzodiazepine structure. Lurasidone is known for its relatively favorable side effect profile compared to other antipsychotics, particularly in terms of metabolic side effects. It is typically administered orally and has a moderate bioavailability, with its pharmacokinetics influenced by food intake. The drug is metabolized primarily by the liver enzyme CYP3A4, which can be affected by other medications that induce or inhibit this enzyme. Common side effects may include sedation, akathisia, and gastrointestinal disturbances. Overall, Lurasidone represents a significant advancement in the management of psychotic disorders, offering a balance between efficacy and tolerability.

Formula: C₂₈H₃₆N₄O₂S

InChI: InChI=1/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1

InChI key: InChIKey=PQXKDMSYBGKCJA-CVTJIBDQSA-N

SMILES: O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1C[C@H]4[C@H](CN5CCN(CC5)C=6C=7C(SN6)=CC=CC7)CCCC4)[H])[H]

Synonyms:

• (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione
• (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
• (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• 2-[[(1R,2R)-2-[[4-(1,2-Benzoisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-(3aS,4R,7S,7aR)-4,7-methano-1H-isoindole-1,3(2H)-dione
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-
• Lurasidone
• 4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione
• Lurasidone Base
• Lurasidone, >=98%
• Lurasidone (SM13496)
• urasidone

Lurasidone

CAS: 367514-87-2

Formula: C₂₈H₃₆N₄O₂S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Orange to Green powder to crystaline

Molecular weight: 492.68

Ref: 3B-L0280

(3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione

CAS: 367514-87-2

Formula: C₂₈H₃₆N₄O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 492.6760

Ref: IN-DA0037AT

Lurasidone

CAS: 367514-87-2

Lurasidone

Purity: 99%

Molecular weight: 492.68g/mol

Ref: 54-OR1028250

Lurasidone

CAS: 367514-87-2

Lurasidone

Purity: ≥98%

Molecular weight: 492.68g/mol

Ref: 54-BUP06576

Lurasidone

CAS: 367514-87-2

Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6

Formula: C₂₈H₃₆N₄O₂S

Purity: 99.78% - 99.91%

Color and Shape: Solid

Molecular weight: 492.68

Ref: TM-T21337

Lurasidone

Controlled Product

CAS: 367514-87-2

Applications Lurasidone (cas# 367514-87-2) is a useful research chemical.

Formula: C₂₈H₃₆N₄O₂S

Color and Shape: Neat

Molecular weight: 492.68

Ref: TR-L474958

Lurasidone

Controlled Product

CAS: 367514-87-2

Lurasidone is an atypical antipsychotic medication, which is a synthetic compound developed through pharmaceutical chemical synthesis. It functions primarily as a dopamine D2 and serotonin 5-HT2A receptor antagonist, while also exhibiting partial agonism at certain serotonin receptors and antagonism at other neurotransmitter sites such as alpha-2 adrenergic receptors.Lurasidone is widely utilized in the medical field for the treatment of psychiatric disorders, notably schizophrenia and bipolar depression. Its multifaceted receptor activity profile helps in modulating neurotransmission imbalances associated with these conditions. By targeting specific neural pathways, lurasidone can effectively alleviate symptoms of psychosis, improve mood stability, and enhance overall cognitive function in patients. Researchers and clinicians value lurasidone for its efficacy in symptom management alongside a favorable side effect profile compared to older antipsychotics. Its pharmacological properties make it an important tool in advancing therapeutic approaches for complex psychiatric disorders.

Formula: C₂₈H₃₆N₄O₂S

Purity: Min. 95%

Molecular weight: 492.68 g/mol

Ref: 3D-SPA51487