CAS 36761-83-8

3-Dechloroethylifosfamide

Description:

3-Dechloroethylifosfamide, with the CAS number 36761-83-8, is a chemical compound that belongs to the class of alkylating agents, specifically a derivative of ifosfamide. It is characterized by its ability to form covalent bonds with DNA, leading to cross-linking and subsequent inhibition of DNA replication and transcription, which is a mechanism utilized in cancer therapy. This compound is typically used in the treatment of various malignancies, including lymphomas and solid tumors. Its structure includes a chloroethyl group, which is crucial for its reactivity and therapeutic efficacy. The compound is generally administered in a clinical setting, and its pharmacokinetics can be influenced by factors such as dosage, administration route, and patient-specific variables. As with many alkylating agents, potential side effects may include myelosuppression, gastrointestinal disturbances, and increased risk of secondary malignancies. Safety and handling precautions are essential due to its cytotoxic nature. Overall, 3-Dechloroethylifosfamide represents an important tool in oncological pharmacotherapy.

Formula: C₅H₁₂ClN₂O₂P

InChI: InChI=1S/C5H12ClN2O2P/c6-2-4-8-11(9)7-3-1-5-10-11/h1-5H2,(H2,7,8,9)

InChI key: InChIKey=DZKGMGPLDJOVCX-UHFFFAOYSA-N

SMILES: N(CCCl)P1(=O)NCCCO1

Synonyms:

• 2-((2-Chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
• 2-(2-Chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• 2-[(2-Chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one
• 2H-1,3,2-oxazaphosphorin-2-amine, N-(2-chloroethyl)tetrahydro-, 2-oxide
• 3-Dechloroethylifosfamide
• Asta 4968
• Dechloroethylcyclophosphamide
• Monochloroethylcyclophosphamide
• N-Dechloroethylcyclophosphamide

N-Dechloroethyl Cyclophosphamide

CAS: 36761-83-8

Formula: C₅H₁₂ClN₂O₂P

Color and Shape: White To Off-White Solid

Molecular weight: 198.59

Ref: 4Z-C-1028

N-Dechloroethyl Cyclophosphamide

CAS: 36761-83-8

Stability Reacts with DMSO
Applications A metabolite of Cyclophosphamide (C988580).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),

Formula: C₅H₁₂ClN₂O₂P

Color and Shape: Neat

Molecular weight: 198.59

Ref: TR-D226400

N-Dechloroethyl cyclophosphamide

CAS: 36761-83-8

N-Dechloroethyl cyclophosphamide is a metabolic inhibitor that is used in the treatment of cancer. It is classified as an alkylating agent and inhibits ribonucleotide reductase, which prevents the production of DNA, RNA, and protein. The chemical ionization technique has been used to measure the concentration of this compound in human liver and urine samples. N-Dechloroethyl cyclophosphamide can be analyzed using chromatography or mass spectrometry methods.

Formula: C₅H₁₂ClN₂O₂P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 198.59 g/mol

Ref: 3D-FD20873

N-Dechloroethyl Cyclophosphamide

CAS: 36761-83-8

Formula: C₅H₁₂ClN₂O₂P

Molecular weight: 198.59

Ref: ST-EA-CP-C37044