CAS 36822-11-4

6-Phenyl-2-thiouracil

Description:

6-Phenyl-2-thiouracil is a chemical compound that belongs to the class of thiouracils, which are derivatives of uracil where a sulfur atom replaces an oxygen atom. This compound is characterized by the presence of a phenyl group at the 6-position of the uracil ring, which contributes to its unique properties. It typically appears as a white to off-white solid and is soluble in organic solvents. 6-Phenyl-2-thiouracil has been studied for its potential biological activities, including its role as an antithyroid agent, as it can inhibit the synthesis of thyroid hormones by interfering with the incorporation of iodine into thyroglobulin. Additionally, it may exhibit antimicrobial and antifungal properties. The compound's structure allows for various interactions with biological systems, making it of interest in medicinal chemistry. Safety data should be consulted for handling and exposure, as with any chemical substance.

Formula: C₁₀H₈N₂OS

InChI: InChI=1S/C10H8N2OS/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)

InChI key: InChIKey=XEKNACRTWJHOCE-UHFFFAOYSA-N

SMILES: O=C1C=C(NC(=S)N1)C2=CC=CC=C2

Synonyms:

• 2,3-Dihydro-6-phenyl-2-thioxo-4(1H)-pyrimidinone
• 2-Mercapto-6-phenyl-1H-pyrimidin-4-one
• 2-Mercapto-6-phenylpyrimidin-4-ol
• 4(1H)-Pyrimidinone, 2,3-dihydro-6-phenyl-2-thioxo-
• 6-Phenylthiouracil
• 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Ai3-26584
• Fenucil
• Nsc 163991
• Nsc 42600
• Phenylthiouracil
• Uracil, 6-phenyl-2-thio-

6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 204.2483

Ref: IN-DA0033DC

2-Mercapto-6-phenyl-pyrimidin-4-ol

CAS: 36822-11-4

2-Mercapto-6-phenyl-pyrimidin-4-ol

Purity: 95%

Molecular weight: 204.25g/mol

Ref: 54-OR346183

6-Phenyl-2-thiouracil

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Molecular weight: 204.25

Ref: 7W-GL2137

6-Phenyl-2-thiouracil

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 204.25

Ref: 3B-P0236

6-Phenyl-2-thiouracil

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Color and Shape: Neat

Molecular weight: 204.248

Ref: 04-C15144400

6-Phenyl-2-Thiouracil

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Molecular weight: 204.25

Ref: 4Z-P-10103

6-​Phenyl-​2-​thiouracil

CAS: 36822-11-4

Applications 6-​Phenyl-​2-​thiouracil is a reagent used in the synthesis of antifungal agents.
References Gullapelli, K. et al.: Int. J. Pharm. Biol. Sci., 4, 59 (2014);

Formula: C₁₀H₈N₂OS

Color and Shape: Off-White

Molecular weight: 204.248

Ref: TR-P337105

6-Phenyl-2-thiouracil

CAS: 36822-11-4

6-Phenyl-2-thiouracil (6PTU) is an alkylthio group that inhibits the growth of microorganisms by binding to DNA. 6PTU binds to the oxygen nucleophiles in DNA and prevents transcription and replication. It also has a positive effect on the synthesis of proteins, which may be due to its ability to regulate gene transcription. 6PTU has been shown to inhibit cell growth in culture by blocking protein synthesis. This drug is used as an analytical method for determining urinary glucose levels in animals because it reacts with glucose in urine samples. The reaction produces a chromatographic peak that can be quantified using an electrochemical detector.

Formula: C₁₀H₈N₂OS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 204.25 g/mol

Ref: 3D-FP08051

4-Hydroxy-2-mercapto-6-phenylpyrimidine

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Purity: 95%

Color and Shape: Solid

Molecular weight: 204.25

Ref: 10-F017162

6-Phenyl-2-Thiouracil

CAS: 36822-11-4

Formula: C₁₀H₈N₂OS

Molecular weight: 204.25

Ref: ST-EA-CP-P201003