CAS 368434-78-0

7-benzyl-1,3-dimethyl-8-morpholin-4-ylpurine-2,6-dione

Description:

7-benzyl-1,3-dimethyl-8-morpholin-4-ylpurine-2,6-dione, with the CAS number 368434-78-0, is a synthetic purine derivative characterized by its complex structure, which includes a purine core substituted with a benzyl group and a morpholine moiety. This compound typically exhibits properties associated with purine analogs, such as potential biological activity, particularly in the context of enzyme inhibition or modulation. It may interact with various biological targets, making it of interest in medicinal chemistry and drug development. The presence of the morpholine ring suggests possible solubility in polar solvents, while the benzyl group may enhance lipophilicity. The compound's structure indicates potential for hydrogen bonding and π-π interactions, which could influence its pharmacokinetic properties. As with many purine derivatives, it may exhibit nucleoside-like behavior, potentially impacting its role in cellular processes. Overall, this compound's unique structural features contribute to its potential applications in therapeutic contexts, particularly in oncology or antiviral research.

Formula: C₁₈H₂₁N₅O₃

Synonyms:

• 7-BENZYL-1,3-DIMETHYL-8-(4-MORPHOLINYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(4-morpholinyl)-7-(phenylmethyl)-
• 7-benzyl-1,3-dimethyl-8-morpholin-4-ylpurine-2,6-dione

PB01

CAS: 368434-78-0

PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.

Formula: C₁₈H₂₁N₅O₃

Color and Shape: Solid

Molecular weight: 355.391

Ref: TM-T204296