CAS 36889-16-4

Gentamicin B1

Description:

Gentamicin B1 is an aminoglycoside antibiotic that is primarily used to treat various bacterial infections, particularly those caused by Gram-negative bacteria. It is derived from the bacterium Micromonospora purpurea and is known for its broad-spectrum antibacterial activity. Gentamicin B1 exhibits a high affinity for bacterial ribosomes, inhibiting protein synthesis, which ultimately leads to bacterial cell death. The substance is typically administered via injection or topical application, depending on the type and severity of the infection. Its solubility in water allows for effective systemic distribution, although it may require careful monitoring due to potential nephrotoxicity and ototoxicity associated with its use. Gentamicin B1 is often part of combination therapy to enhance efficacy and reduce the risk of resistance. As with other aminoglycosides, its pharmacokinetics can be influenced by factors such as renal function and age, necessitating dose adjustments in certain populations. Overall, Gentamicin B1 remains a critical agent in the treatment of serious infections, particularly in hospital settings.

Formula: C₂₀H₄₀N₄O₁₀

InChI: InChI=1S/C20H40N4O10/c1-6(21)14-10(26)9(25)11(27)19(32-14)34-16-8(23)4-7(22)15(12(16)28)33-18-13(29)17(24-3)20(2,30)5-31-18/h6-19,24-30H,4-5,21-23H2,1-3H3/t6-,7-,8+,9+,10+,11-,12-,13-,14-,15+,16-,17-,18-,19-,20+/m1/s1

InChI key: InChIKey=ABCLPPNEPBAKRL-FGMXNJDGSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@]([C@@H](C)N)([C@@H](O)[C@H](O)[C@H]2O)[H])[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Synonyms:

• O-6-Amino-6,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine
• Gentamycin B1
• Gentamicin B1
• D-Streptamine, O-6-amino-6,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-

Gentamicin B1

CAS: 36889-16-4

Formula: C₂₀H₄₀N₄O₁₀

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white or yellow powder

Molecular weight: 496.55

Ref: 7W-GX9075

Gentamycin Sulfate EP Impurity C (Gentamicin B1)

CAS: 36889-16-4

Formula: C₂₀H₄₀N₄O₁₀

Molecular weight: 496.56

Ref: 4Z-G-044001

Gentamicin B1 Acetate Salt

CAS: 36889-16-4

Applications Gentamicin B1 Acetate Salt is the salt form of Gentamicin B1 (G360575), which is a derivative of Gentamicin (G360605), an aminoglycoside antibiotic.
References Jarai, M., et al.: Hung. Teljes, HU 34989 A2 19850528 (1985); Cooper, D., et al.: U.S., US 3915955 A 19751028. (1975)

Formula: C₂₀H₄₀N₄O₁₀•x(C₂H₄O₂)

Color and Shape: Neat

Molecular weight: 496.556005

Ref: TR-G360560

Gentamicin B1

CAS: 36889-16-4

Gentamicin B1 is a gentamicin antibiotic that is used to treat skin cancer. It inhibits bacterial growth by binding to the 50S ribosomal subunit and blocking protein synthesis. Gentamicin B1 has shown clinical response in patients with wild-type strains of Streptococcus faecalis, but not in those with a mutant strain. The mechanism of action for this drug may involve its ability to inhibit epidermal growth factor (EGF) production. Gentamicin B1 also has been shown to inhibit the proliferation of human cancer cells and induce apoptosis in some tumor cells.

Formula: C₂₀H₄₀N₄O₁₀

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 496.55 g/mol

Ref: 3D-AG46304

Gentamicine Sulphate EP Impurity C

CAS: 36889-16-4

Formula: C₂₀H₄₀N₄O₁₀

Molecular weight: 496.6

Ref: ST-EA-CP-G33017