CAS 3690-10-6: Zebularine

Description: Zebularine, with the CAS number 3690-10-6, is a nucleoside analog that has garnered interest in the field of epigenetics and cancer research. It is structurally related to cytidine, featuring a unique modification that enhances its stability and bioavailability. Zebularine is known for its ability to inhibit DNA methyltransferases, enzymes responsible for adding methyl groups to DNA, which can lead to gene silencing. This property makes it a valuable tool for studying gene expression and potential therapeutic applications in cancer treatment, where abnormal methylation patterns are often observed. Zebularine is typically administered in vitro and has shown promise in reactivating silenced genes, thereby restoring normal cellular functions. Additionally, it has been investigated for its effects on cell proliferation and differentiation. However, its use in clinical settings is still under exploration, and further studies are needed to fully understand its pharmacological properties and potential side effects. Overall, zebularine represents a significant compound in the ongoing research into epigenetic modulation and its implications for disease treatment.

Formula: C₉H₁₂N₂O₅

InChI: InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1

InChI key: InChIKey=RPQZTTQVRYEKCR-WCTZXXKLSA-N

SMILES: O=C1N=CC=CN1C2OC(CO)C(O)C2O

Synonyms:

• 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-1,2-dihydropyrimidin-2-one
• 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-2-pyrimidone
• 1-b-D-Ribofuranosyl-2(1H)-pyrimidinone
• 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2(1H)-pyrimidinone
• 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2-pyrimidinone
• 2(1H)-Pyrimidinone, 1-.beta.-D-ribofuranosyl-
• 2(1H)-Pyrimidinone, 1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Deoxyuridine
• NSC 309132
• Pyrimidin-2-one b-Ribofuranoside
• Pyrimidin-2-one β-<span class="text-smallcaps">D</span>-ribofuranoside
• Uridine, 4-deoxy-
• Zebularine
• 1-(β-D-Ribofuranosyl)-2-pyrimidone
• 1-(beta-D-Ribofuranosyl)pyrimidin-2(1H)-one
• 2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-

Zebularine

CAS: 3690-10-6

• Formula: C₉H₁₂N₂O₅
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 228.20

ZEBULARINE

CAS: 3690-10-6

• Formula: C₉H₁₂N₂O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 228.20197999999996

4-Deoxyuridine

CAS: 3690-10-6

• Formula: C₉H₁₂N₂O₅
• Molecular weight: 228.20

Zebularine

CAS: 3690-10-6

• Purity: ≥98%
• Molecular weight: 228.2g/mol

Zebularine

CAS: 3690-10-6

• Color and Shape: Pale Yellow Solid
• Molecular weight: 228.20g/mol

ZEBULARINE

CAS: 3690-10-6

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 228.20399475097656

Zebularine

CAS: 3690-10-6

• Formula: C₉H₁₂N₂O₅
• Molecular weight: 228.21

Zebularine

CAS: 3690-10-6

Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.

• Formula: C₉H₁₂N₂O₅
• Purity: 100% - 99.84%
• Color and Shape: Solid
• Molecular weight: 228.2

Zebularine

CAS: 3690-10-6

Applications It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent. References Driscoll, …

• Formula: C₉H₁₂N₂O₅
• Color and Shape: Neat
• Molecular weight: 228.20

4-Deoxyuridine

CAS: 3690-10-6

A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, …

• Formula: C₉H₁₂N₂O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 228.21 g/mol