CAS 3693-39-8

Flucloronide

Description:

Flucloronide is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatology for the treatment of various skin conditions, including psoriasis and eczema. It is characterized by its ability to inhibit the proliferation of skin cells and reduce inflammation, making it effective in managing symptoms associated with these disorders. The compound is typically formulated as a topical ointment or cream, allowing for localized treatment with minimal systemic absorption. Flucloronide's mechanism of action involves the modulation of gene expression related to inflammatory processes, leading to decreased production of pro-inflammatory cytokines. Its chemical structure includes a fluorinated steroid backbone, which enhances its potency and efficacy compared to non-fluorinated corticosteroids. While generally well-tolerated, potential side effects may include skin irritation or atrophy with prolonged use. As with any corticosteroid, it is important to use Flucloronide under medical supervision to mitigate risks and ensure appropriate therapeutic outcomes.

Formula: C₂₄H₂₉Cl₂FO₅

InChI: InChI=1S/C24H29Cl2FO5/c1-20(2)31-19-9-13-14-8-16(27)15-7-12(29)5-6-21(15,3)23(14,26)17(25)10-22(13,4)24(19,32-20)18(30)11-28/h5-7,13-14,16-17,19,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChI key: InChIKey=NJNWEGFJCGYWQT-VSXGLTOVSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](Cl)([C@@H](Cl)C3)[C@]5(C)C([C@@H](F)C4)=CC(=O)C=C5)[H])[H]

Synonyms:

• (4bR,6bS,9aR,12S)-4b,5-dichloro-12-fluoro-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (6α,11β,16α)-9,11-Dichloro-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• 6α-Fluoro-9α,11β-dichloropregna-1,4-diene-16α,17α,21-triol-3,20-dione 16,17-acetonide
• 9,11β-Dichloro-6α-fluoro-16α,17,21-trihydroxypregna-1,4-diene-3,20-dione 16,17-acetal with acetone
• 9,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
• 9-Alpha,11-Beta-Dichloro-6-Alpha-Fluoro-21-Hydroxy-16-Alpha,17-Alpha-Isopropylidenedioxypregna-1,4-Diene-3,20-Dione
• 9α, 11β-Dichloro-6α-fluoro-16α, 17α, 21-trihydroxypregna-1,4-diene-3, 20-dione-16, 17-acetonide
• Flucloronide
• Flucortolone acetonide
• Pregna-1,4-diene-3,20-dione, 9,11-dichloro-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9,11β-dichloro-6α-fluoro-16α,17,21-trihydroxy-, cyclic 16,17-acetal with acetone
• Rs 2252

Flucloronide (Fluclorolone Acetonide)

CAS: 3693-39-8

Formula: C₂₄H₂₉Cl₂FO₅

Molecular weight: 487.39

Ref: 4Z-F-071009

Flucloronide

CAS: 3693-39-8

Flucloronide is a corticosteroid for topical use on the skin. It has anti-inflammatory properties.

Formula: C₂₄H₂₉Cl₂FO₅

Color and Shape: Solid

Molecular weight: 487.39

Ref: TM-T25426

Flucloronide

Controlled Product

CAS: 3693-39-8

Formula: C₂₄H₂₉Cl₂FO₅

Color and Shape: Neat

Molecular weight: 487.389

Ref: TR-F418900

Flucloronide

CAS: 3693-39-8

Flucloronide is a synthetic corticosteroid that belongs to the class of anti-infective agents and has been shown to have strong anti-inflammatory properties. It has been used in the treatment of bacterial and fungal infections, as well as autoimmune diseases such as alopecia areata. Flucloronide is also used to treat choroidal neovascularization, which is caused by damage or inflammation to the retina. The drug is delivered topically through microparticles that are biocompatible with mammalian tissue. Flucloronide binds to glucocorticoid receptors on cells and inhibits the production of inflammatory compounds, such as prostaglandins and leukotrienes. This prevents inflammation, swelling, redness, heat, and pain.

Formula: C₂₄H₂₉Cl₂FO₅

Purity: Min. 95%

Molecular weight: 487.39 g/mol

Ref: 3D-FF23318