CAS 36945-98-9

Icilin

Description:

Icilin is a synthetic compound known for its role as a potent activator of the TRPM8 (transient receptor potential melastatin 8) ion channel, which is involved in the sensation of cold and menthol-like cooling effects. It is classified as a chemical compound with a specific structure that allows it to interact with biological systems, particularly in sensory neurons. Icilin is often studied in the context of pain modulation and thermosensation, making it of interest in pharmacological research. The compound is typically characterized by its ability to induce a cooling sensation, similar to menthol, and is used in various studies to explore mechanisms of cold perception and potential therapeutic applications. Its CAS number, 36945-98-9, serves as a unique identifier for regulatory and research purposes. As with many chemical substances, safety and handling precautions are essential when working with Icilin in laboratory settings.

Formula: C₁₆H₁₃N₃O₄

InChI: InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)

InChI key: InChIKey=RCEFMOGVOYEGJN-UHFFFAOYSA-N

SMILES: O=C1NC(=CCN1C2=C(O)C=CC=C2)C3=CC(N(=O)=O)=CC=C3

Synonyms:

• 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one
• 2(1H)-Pyrimidinone, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-
• 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
• Ag 3-5
• Icilin
• 3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

Icilin

CAS: 36945-98-9

Formula: C₁₆H₁₃N₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 311.2921

Ref: IN-DA00BZAB

ICILIN

CAS: 36945-98-9

ICILIN

Purity: ≥95%

Molecular weight: 311.29g/mol

Ref: 54-BUP06075

ICILIN

CAS: 36945-98-9

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

Formula: C₁₆H₁₃N₃O₄

Purity: 98.45% - ≥95%

Color and Shape: Light Yellow Solid

Molecular weight: 311.29

Ref: TM-T1814

Icilin

Controlled Product

CAS: 36945-98-9

Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels.
References Noncovich, A., et al.: Bioorganic Med. Chem. Lett., 27, 3931-38 (2017);

Formula: C₁₆H₁₃N₃O₄

Color and Shape: White To Light Yellow

Molecular weight: 311.29

Ref: TR-I164505

Icilin - Bio-X ™

CAS: 36945-98-9

Icilin is a transient receptor potential M8 (TRPM8) agonist drug that is used for the treatment of pruritis. This drug has shown to be effective in producing an extreme cold sensation in both human and animal models. It is used in research for studying TRP channels.

Formula: C₁₆H₁₃N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 311.29 g/mol

Ref: 3D-BI164563

Icilin

CAS: 36945-98-9

TRPM8 agonist

Formula: C₁₆H₁₃N₃O₄

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 311.29 g/mol

Ref: 3D-FI66396

3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

CAS: 36945-98-9

Formula: C₁₆H₁₃N₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 311.297

Ref: 10-F375702