CAS 36945-98-9: Icilin

Description: Icilin is a synthetic compound known for its role as a potent activator of the TRPM8 (transient receptor potential melastatin 8) ion channel, which is involved in the sensation of cold and menthol-like cooling effects. It is classified as a chemical compound with a specific structure that allows it to interact with biological systems, particularly in sensory neurons. Icilin is often studied in the context of pain modulation and thermosensation, making it of interest in pharmacological research. The compound is typically characterized by its ability to induce a cooling sensation, similar to menthol, and is used in various studies to explore mechanisms of cold perception and potential therapeutic applications. Its CAS number, 36945-98-9, serves as a unique identifier for regulatory and research purposes. As with many chemical substances, safety and handling precautions are essential when working with Icilin in laboratory settings.

Formula: C₁₆H₁₃N₃O₄

InChI: InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)

InChI key: InChIKey=RCEFMOGVOYEGJN-UHFFFAOYSA-N

SMILES: O=C1NC(=CCN1C=2C=CC=CC2O)C=3C=CC=C(C3)N(=O)=O

Synonyms:

• 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one
• 2(1H)-Pyrimidinone, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-
• 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
• Ag 3-5
• Icilin
• 3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

ICILIN

CAS: 36945-98-9

• Formula: C₁₆H₁₃N₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 311.2921

ICILIN

CAS: 36945-98-9

• Purity: 97.6%
• Molecular weight: 311.29g/mol

ICILIN

CAS: 36945-98-9

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

• Formula: C₁₆H₁₃N₃O₄
• Purity: 97.61% - ≥95%
• Color and Shape: Light Yellow Solid
• Molecular weight: 311.29

Icilin

CAS: 36945-98-9

Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels. References Noncovich, …

• Formula: C₁₆H₁₃N₃O₄
• Color and Shape: White To Light Yellow
• Molecular weight: 311.29

3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

CAS: 36945-98-9

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 311.2969970703125

Icilin - Bio-X ™

CAS: 36945-98-9

Icilin is a transient receptor potential M8 (TRPM8) agonist drug that is used for the …

• Formula: C₁₆H₁₃N₃O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 311.29 g/mol

Icilin

CAS: 36945-98-9

TRPM8 agonist

• Formula: C₁₆H₁₃N₃O₄
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 311.29 g/mol