CAS 37025-55-1

Carbetocin

Description:

Carbetocin is a synthetic analog of oxytocin, a peptide hormone that plays a crucial role in various physiological processes, including childbirth and lactation. It is characterized by its structure, which consists of a chain of nine amino acids, similar to that of oxytocin, but with a modification that enhances its stability and prolongs its action in the body. Carbetocin is primarily used in clinical settings to prevent uterine atony and reduce postpartum hemorrhage following cesarean sections. Its mechanism of action involves stimulating uterine contractions and promoting milk ejection during breastfeeding. The substance is administered via injection, and its pharmacokinetics are influenced by factors such as dosage and route of administration. Carbetocin is generally well-tolerated, but like any medication, it may have side effects, including nausea, headache, and potential allergic reactions. Its use is contraindicated in certain conditions, such as hypersensitivity to the drug or its components. Overall, carbetocin represents an important therapeutic agent in obstetric care.

Formula: C₄₅H₆₉N₁₁O₁₂S

InChI: InChI=1/C45H69N11O12S/c1-6-25(4)38-44(67)50-28(15-16-34(46)58)40(63)51-30(21-35(47)59)41(64)53-31(23-69-18-8-10-37(61)55(5)33(43(66)54-38)20-26-11-13-27(57)14-12-26)45(68)56-17-7-9-32(56)42(65)52-29(19-24(2)3)39(62)49-22-36(48)60/h11-14,24-25,28-33,38,57H,6-10,15-23H2,1-5H3,(H2,46,58)(H2,47,59)(H2,48,60)(H,49,62)(H,50,67)(H,51,63)(H,52,65)(H,53,64)(H,54,66)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1

SMILES: CC[C@H](C)[C@H]1C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(=N)O)C(=N[C@@H](CSCCCC(=O)N(C)[C@@H](Cc2ccc(cc2)O)C(=N1)O)C(=O)N1CCC[C@H]1C(=N[C@@H](CC(C)C)C(=NCC(=N)O)O)O)O)O)O

Synonyms:

• 1-{[(3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-(4-hydroxybenzyl)-16-methyl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}-L-prolyl-L-leucylglycinamide
• glycinamide, 1-[[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-15-[(4-hydroxyphenyl)methyl]-16-methyl-12-[(1S)-1-methylpropyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloeicos-3-yl]carbonyl]-L-prolyl-L-leucyl-
• (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin Trifluoroacetate Salt；
• [2-O-Methyltyrosine]-deamino-1-carba-oxytocin
• 1-Carbaoxytocin, 1-butanoic acid-2-(O-methyl-L-tyrosine)-
• Carbetocine
• Carbetocino
• Deamino-2-O-methyltyrosine-1-carbaoxytocin
• Depotocin
• CarbetocinAcetate

Carbetocin

CAS: 37025-55-1

This synthetic oxytocin analog shows a prolonged effect due to an increased resistance to enzymatic cleavage. Carbetocin is highly effective in preventing post-partum hemorrhage after vaginal delivery.

Formula: C₄₅H₆₉N₁₁O₁₂S

Purity: 95.6%

Color and Shape: White Lyophilisate

Molecular weight: 988.18

Ref: 01-4040269

Carbetocin

CAS: 37025-55-1

Formula: C₄₅H₆₉N₁₁O₁₂S

Color and Shape: White To Off-White Solid

Molecular weight: 988.17

Ref: 4Z-PC-279001

Carbetocin acetate

CAS: 37025-55-1

Formula: ·16(freebase)

Purity: ≥ 93.0%

Color and Shape: White to off-white powder or solid

Ref: 7W-GX3727

Carbetocin

Controlled Product

CAS: 37025-55-1

Formula: C₄₅H₆₉N₁₁O₁₂S

Color and Shape: Neat

Molecular weight: 988.16

Ref: 04-C11000200

Carbetocin Acetate

CAS: 37025-55-1

Formula: C₄₅H₆₉N₁₁O₁₂S

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 988.18

Ref: BP-BPPG014

Carbetocin

CAS: 37025-55-1

Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.

Formula: C₄₅H₆₉N₁₁O₁₂S

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 988.16

Ref: TM-T7601

Carbetocin

CAS: 37025-55-1

Applications An obstetric drug used to control postpartum hemorrhaging.
References Sanz-Nebot, V., et al.: Anal. Bioanal. Chem., 377, 306 (2003), Gimpl, G., et al.: Eur. J. Pharmacol., 510, 9 (2005), Handler, J., et al.: Theriogenol., 66, 1397 (2006), Klenerova, V., et al.: J. Physiol. Pharmacol., 60, 57 (2009),

Formula: C₄₅H₆₉N₁₁O₁₂S

Color and Shape: Neat

Molecular weight: 988.16

Ref: TR-C175925

1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin

CAS: 37025-55-1

1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin (BMT) is a synthetic analog of oxytocin. Oxytocin is a hormone that is produced in the hypothalamus and released by the pituitary gland to stimulate uterine contractions and milk letdown in mammals. 1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin has been shown to bind to the oxytocin receptor and stimulate the release of insulin, which may be useful for treating type 2 diabetes. BMT also stimulates epidermal growth factor (EGF) production and induces skin cell growth. It has been used as an animal health drug for stimulating appetite, increasing weight gain, reducing inflammation, and lowering blood pressure.

Formula: C₄₅H₆₉N₁₁O₁₂S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 988.16 g/mol

Ref: 3D-FB19694