CAS 3704-01-6
:4-Desacetyl Vincristine
Description:
4-Desacetyl Vincristine, with the CAS number 3704-01-6, is a derivative of the alkaloid vincristine, which is primarily derived from the Madagascar periwinkle plant, Catharanthus roseus. This compound is characterized by its complex tetracyclic structure, which includes a vinblastine-like core. It exhibits significant antitumor activity, making it of interest in cancer research and treatment, particularly in hematological malignancies. The compound functions by inhibiting microtubule formation during cell division, thereby disrupting the mitotic process. Its pharmacological properties are influenced by its ability to interact with tubulin, leading to cell cycle arrest. Additionally, 4-Desacetyl Vincristine is known for its potential side effects, which can include neurotoxicity and myelosuppression, similar to other vinca alkaloids. The compound's solubility, stability, and bioavailability are critical factors that influence its therapeutic efficacy and are subjects of ongoing research. Overall, 4-Desacetyl Vincristine represents a significant area of study in the development of chemotherapeutic agents.
Formula:C45H57N4O13S
Synonyms:- O4-Deacetyl-22-oxo-vincaleukoblastine
- 4-Deacetyl Leurocristine
- 4-Deacetylvincristine
- 4-Desacetyl Vincristine Methosulfate
- Vincristine EP-D
- 4-Desacetyl Vincristine
- O4-Deacetyl-22-oxo-vincaleukoblastine Methosulfate
- 4-Deacetylvincristin
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Found 3 products.
4-Desacetyl Vincristine Methosulfate
CAS:<p>Applications A metabolite of Vincristine in bile. Antitumor agent used against human colon carcinoma.<br>References Houghton, J.A., et al.: Anal. Biochem., 134, 450 (1983), Sethi, V.S., et al.: Cancer Res., 45, 5386 (1985), Horton, J.K., et al.: Biochem. Pharmacol., 38, 1727 (1989),<br></p>Formula:C44H54N4O9Color and Shape:NeatMolecular weight:782.92
