Defensin-4 (human) trifluoroacetate salt is a synthetic peptide derived from the human defensin family, which plays a crucial role in the innate immune response. This peptide exhibits antimicrobial properties, particularly against bacteria, fungi, and some viruses, making it significant in host defense mechanisms. The trifluoroacetate salt form enhances its solubility and stability, facilitating its use in various biochemical applications. Defensin-4 is characterized by a compact structure stabilized by disulfide bonds, which contribute to its biological activity. The peptide typically contains a series of positively charged amino acids, allowing it to interact effectively with negatively charged microbial membranes. Its mechanism of action often involves disrupting microbial cell membranes, leading to cell lysis. Additionally, defensins are known to modulate immune responses, influencing inflammation and cell signaling pathways. Overall, Defensin-4 is a vital component of the immune system, with potential therapeutic applications in treating infections and inflammatory diseases.

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
1
It induces migration of monocytes
in vitro
when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.
2
β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.
3
It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells
in vitro
when used at a concentration of 10 μg/ml and by rat mast cells
in vivo
following a 500 ng intradermal dose.
4
It also inhibits growth of
E. coli
,
P. aeruginosa
, and
S. aureus
with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of
S. carnosus
(MIC = 4.5 μg/ml), and of
C. albicans
with a minimum fungicidal concentration (MFC) value of 7.5 μM.
2
,
5

-Defensin-4 (human) (trifluoroacetate salt)

370570-43-7: Defensin-4 (human) trifluoroacetate salt is a synthetic peptide derived from the human defensin family, which plays a crucial role in the innate immune response. This peptide exhibits antimicrobial properties, particularly against bacteria, fungi, and some viruses, making it significant in host defense mechanisms. The trifluoroacetate salt form enhances its solubility and stability, facilitating its use in various biochemical applications. Defensin-4 is characterized by a compact structure stabilized by disulfide bonds, which contribute to its biological activity. The peptide typically contains a series of positively charged amino acids, allowing it to interact effectively with negatively charged microbial membranes. Its mechanism of action often involves disrupting microbial cell membranes, leading to cell lysis. Additionally, defensins are known to modulate immune responses, influencing inflammation and cell signaling pathways. Overall, Defensin-4 is a vital component of the immune system, with potential therapeutic applications in treating infections and inflammatory diseases.

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal

CAS 370570-43-7

-Defensin-4 (human) (trifluoroacetate salt)

β-Defensin-4 (human) (trifluoroacetate salt)

Ref: TM-T35453