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CAS 37076-68-9

:

(R)-Ftorafur

Description:
(R)-Ftorafur, also known as (R)-5-fluoro-2'-deoxyuridine, is a fluorinated pyrimidine derivative primarily used in cancer treatment as a chemotherapeutic agent. It acts as a prodrug, which means it is metabolized in the body to exert its therapeutic effects. The compound is characterized by its ability to inhibit thymidylate synthase, an enzyme crucial for DNA synthesis, thereby interfering with the proliferation of cancer cells. (R)-Ftorafur is typically administered in combination with other chemotherapeutic agents to enhance its efficacy. Its stereochemistry, indicated by the (R) designation, plays a significant role in its biological activity and pharmacokinetics. The substance is generally well-absorbed and has a favorable distribution in tissues, although its metabolism can vary among individuals. Safety and efficacy profiles are established through clinical trials, and like many chemotherapeutic agents, it may have side effects that require monitoring. Overall, (R)-Ftorafur represents an important tool in the arsenal against certain types of cancer, particularly in combination therapies.
Formula:C8H9FN2O3
InChI:InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)/t6-/m1/s1
InChI key:InChIKey=WFWLQNSHRPWKFK-ZCFIWIBFSA-N
SMILES:O=C1N(C=C(F)C(=O)N1)[C@H]2CCCO2
Synonyms:
  • 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-
  • 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-[(2R)-tetrahydro-2-furanyl]-
  • 5-Fluoro-1-[(2R)-tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
  • NSC 200695
  • R-1-(Tetrahydrofuran-2-yl)-5-fluorouracil
  • Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-, (R)-
  • (R)-Ftorafur
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Found 1 products.
  • Tegafur - Bio-X ™
    Biosynth
    + Info

    Tegafur - Bio-X ™

    CAS:
    <p>Tegafur is an antineoplastic agent that is used for the treatment of gastric and colorectal cancers in combination with other medications. This drug is a prodrug of 5-fluorouracil and has anticancer properties by inhibiting thymidylate synthase during DNA synthesis. Additionally, Tegafur causes disruptions of RNA functions.<br><br>Tegafur is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>
    Formula:C8H9FN2O3
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:200.17 g/mol

    Ref: 3D-BT166256

    10mg
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