CAS 37081-76-8

7-Hydroxyamoxapine

Description:

7-Hydroxyamoxapine is a chemical compound that belongs to the class of dibenzodiazepines and is primarily recognized for its pharmacological properties. It is an active metabolite of amoxapine, an antidepressant that exhibits both antidepressant and antipsychotic effects. The compound features a hydroxyl group at the 7-position of the dibenzodiazepine structure, which contributes to its biological activity. 7-Hydroxyamoxapine is known to interact with various neurotransmitter systems, including serotonin and norepinephrine reuptake inhibition, which is significant in the treatment of mood disorders. Its chemical structure allows for potential binding to dopamine receptors, which may account for its antipsychotic effects. The compound is typically studied in the context of its therapeutic applications and side effects, as well as its metabolic pathways in the human body. As with many pharmacologically active substances, understanding its characteristics, including solubility, stability, and interaction with other drugs, is crucial for its safe and effective use in clinical settings.

Formula: C₁₇H₁₆ClN₃O₂

InChI: InChI=1S/C17H16ClN3O2/c18-11-1-4-15-13(9-11)17(21-7-5-19-6-8-21)20-14-3-2-12(22)10-16(14)23-15/h1-4,9-10,19,22H,5-8H2

InChI key: InChIKey=MEUGUMOVYNSGEW-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(=NC=3C(OC2=CC1)=CC(O)=CC3)N4CCNCC4

Synonyms:

• 2-Chlor-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepin-7-ol
• 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepin-7-ol
• 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepin-7-ol
• 7-Hydroxyamoxapin
• 7-Hydroxyamoxapine
• Dibenz(b,f)(1,4)oxazepin-7-ol, 2-chloro-11-(1-piperazinyl)-

7-Hydroxy Amoxapine

Controlled Product

CAS: 37081-76-8

Applications A metabolite of Amoxapine.
References Hansen, E., et al.: Drug Metab. Dispos.,15, 97 (1987), Hansen, E., et al.: Xenobiotica, 25, 1081 (1995), Moody, J., et al.: Drug Metab. Dispos., 27, 1157 (1999),

Formula: C₁₇H₁₆ClN₃O₂

Color and Shape: Neat

Molecular weight: 329.78

Ref: TR-H797800

Amoxapine 7-Hydroxy Impurity

CAS: 37081-76-8

Formula: C₁₇H₁₆ClN₃O₂

Molecular weight: 329.78

Ref: ST-EA-CP-A19003