CAS 37085-48-6

2-O-methylthymidine

Description:

2-O-Methylthymidine is a modified nucleoside, specifically a derivative of thymidine, which is one of the building blocks of DNA. This compound features a methoxy group (-OCH3) at the 2' position of the ribose sugar, which distinguishes it from regular thymidine. The presence of the methoxy group can influence the compound's biochemical properties, such as its stability, solubility, and interaction with enzymes and nucleic acids. 2-O-Methylthymidine is often studied for its potential applications in molecular biology and medicinal chemistry, particularly in the context of antiviral and anticancer research. Its structural modifications may enhance its efficacy as a therapeutic agent or as a tool in nucleic acid research. Additionally, the compound is characterized by its ability to participate in various chemical reactions typical of nucleosides, including phosphorylation and incorporation into oligonucleotides. Overall, 2-O-Methylthymidine represents an important compound in the study of nucleoside analogs and their biological implications.

Formula: C₁₁H₁₆N₂O₅

InChI: InChI=1/C11H16N2O5/c1-6-4-13(11(17-2)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,3,5H2,1-2H3/t7-,8+,9+/m0/s1

InChI key: OVADECQWSOWNFN-DJLDLDEBSA-N

SMILES: CC1=CN(C(=NC1=O)OC)[C@H]2C[C@@H]([C@H](O2)CO)O

Synonyms:

• O(2)-Methyldeoxythymidine
• 2-Mdot
• 4(1H)-Pyrimidinone, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-
• 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2-methoxy-5-methylpyrimidin-4(1H)-one