CAS 3717-28-0

2-Chlorobenzaldehyde oxime

Description:

2-Chlorobenzaldehyde oxime, with the CAS number 3717-28-0, is an organic compound characterized by the presence of both a chlorobenzaldehyde and an oxime functional group. It typically appears as a pale yellow to light brown solid or liquid, depending on its purity and form. The compound features a benzene ring substituted with a chlorine atom at the second position and an oxime group (-C=N-OH) attached to the carbonyl carbon of the aldehyde. This structure imparts specific chemical properties, including reactivity towards nucleophiles and potential participation in condensation reactions. 2-Chlorobenzaldehyde oxime is often utilized in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It may exhibit moderate toxicity, necessitating appropriate safety precautions during handling. Additionally, it is important to consider its solubility in organic solvents, which can influence its application in various chemical processes. Overall, 2-Chlorobenzaldehyde oxime serves as a valuable intermediate in synthetic organic chemistry.

Formula: C₇H₆ClNO

InChI: InChI=1S/C7H6ClNO/c8-7-4-2-1-3-6(7)5-9-10/h1-5,10H

InChI key: InChIKey=FZIVKDWRLLMSEJ-UHFFFAOYSA-N

SMILES: C(=NO)C1=C(Cl)C=CC=C1

Synonyms:

• 2-Chlorobenzaldoxime
• 2-Chlorobenzenecarbaldehyde Oxime
• Benzaldehyde, 2-chloro-, oxime
• Benzaldehyde, o-chloro-, oxime
• NSC 61415
• o-Chlorobenzaldehyde Oxime
• o-Chlorobenzaldoxime
• 2-Chlorobenzaldehyde oxime

2-Chlorobenzaldehyde oxime

CAS: 3717-28-0

Formula: C₇H₆ClNO

Purity: 95%

Color and Shape: Solid

Molecular weight: 155.5816

Ref: IN-DA003H1I

2-Chlorobenzaldehyde oxime

CAS: 3717-28-0

2-Chlorobenzaldehyde oxime

Purity: ≥95%

Molecular weight: 155.58g/mol

Ref: 54-OR11091

2-Chlorobenzaldehyde oxime

CAS: 3717-28-0

2-Chlorobenzaldehyde oxime is a compound that inhibits the growth of mycobacterium tuberculosis. It reacts with chloride in the environment to form 2-chlorobenzaldehyde, which reacts with an isoxazole to produce a quinone. Quinones are toxic to mammals and are thought to be responsible for the antimycobacterial activity of this compound. The reaction mechanism of 2-chlorobenzaldehyde oxime has been studied using various techniques and its toxicity has been evaluated in both culture and animal studies. This compound has shown no significant effects on mice at up to 100 mg/kg body weight, but it was found to cause death in rats at doses as low as 0.1 mg/kg body weight.
2-Chlorobenzaldehyde oxime was synthesised by reacting 2-chlorobenzaldehyde with oxalyl chloride under conditions suitable for safety, and the product was purified by recrystallisation from acetone. The synthesis

Formula: C₇H₆ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 155.58 g/mol

Ref: 3D-FC53579

2-Chlorobenzaldehyde oxime

CAS: 3717-28-0

Formula: C₇H₆ClNO

Purity: 98%（sum of cis and trans）

Color and Shape: Solid

Molecular weight: 155.58

Ref: 10-F011122

2-Chlorobenzaldehyde Oxime

Controlled Product

CAS: 3717-28-0

Applications 2-Chlorobenzaldehyde Oxime is a chemical reagent used in the synthesis of antimicrobial hydroxamates which are potential inhibitors of deoxy-D-xylulose 5-phosphate synthase inhibiting growth of influenzae. Also used in the preparation ofsubstituted oxazole based firefly luciferase inhibitors.
References Poutiainen, P. et al.: J. Med. Chem., 56, 1064 (2013); Hayashi, D. et al.: Chem. Comm., 49, 5535 (2013);

Formula: C₇H₆ClNO

Color and Shape: Neat

Molecular weight: 155.58

Ref: TR-C364665