CAS 371935-74-9

3-[4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Description:

3-[4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl]phenol, with CAS number 371935-74-9, is a chemical compound characterized by its complex structure, which includes a phenolic group and a morpholine moiety. This compound features a fused pyrido-furo-pyrimidine core, contributing to its potential biological activity. The presence of the morpholine ring suggests that it may exhibit properties relevant to medicinal chemistry, possibly acting as a ligand or inhibitor in various biological pathways. Its phenolic hydroxyl group may also impart antioxidant properties. The compound's solubility, stability, and reactivity can be influenced by the functional groups present, making it of interest in drug design and development. Additionally, the specific arrangement of heterocycles and substituents may affect its pharmacokinetic and pharmacodynamic profiles, which are critical for therapeutic applications. Overall, this compound represents a unique scaffold that could be explored for its potential in pharmaceutical research.

Formula: C₁₉H₁₆N₄O₃

InChI: InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2

InChI key: InChIKey=TUVCWJQQGGETHL-UHFFFAOYSA-N

SMILES: OC=1C=C(C=2N=C3C(=C(N2)N4CCOCC4)OC=5C3=CC=CN5)C=CC1

Synonyms:

• 3-[4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl]phenol
• 3-[4-(4-Morpholinylpyrido)[3',2':4,5]Furo[3,2-D]Pyrimidin-2-Yl]Phenol Hydrochloride
• Phenol, 3-[4-(4-morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl]-
• Pi 103
• Pik 103
• 3-(4-Morpholinopyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol

3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl]phenol

CAS: 371935-74-9

Formula: C₁₉H₁₆N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 348.3553

Ref: IN-DA0035HJ

PI-103

CAS: 371935-74-9

PI-103

Purity: ≥95%

Molecular weight: 348.36g/mol

Ref: 54-BUP15435

PI-103

CAS: 371935-74-9

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).

Formula: C₁₉H₁₆N₄O₃

Purity: 97.79% - 99.3%

Color and Shape: Solid

Molecular weight: 348.36

Ref: TM-T6143

PI103

CAS: 371935-74-9

Ref: 7W-GW6652

3-(4-MORPHOLINOPYRIDO[3′,2′:4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL

CAS: 371935-74-9

Formula: C₁₉H₁₆N₄O₃

Purity: 98%

Molecular weight: 348.362

Ref: 10-F386344

PI 103-D8

Controlled Product

CAS: 371935-74-9

Formula: C₁₉D₈H₈N₄O₃

Color and Shape: Neat

Molecular weight: 356.405

Ref: TR-P400002

PI-103

CAS: 371935-74-9

PI-103 is a potent inducer of apoptosis. It has low potency and is selective for solid tumours, such as breast cancer. PI-103 inhibits the mitochondrial membrane potential by binding to the voltage-dependent anion channel (VDAC) in the outer mitochondrial membrane. PI-103 also inhibits protein synthesis and induces cell death by activating caspase 9 and caspase 3. PI-103 is also used to treat viral infections, such as hepatitis C virus, and bacterial infections, including tuberculosis.

Formula: C₁₉H₁₆N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 348.36 g/mol

Ref: 3D-WPA93574