CAS 37211-65-7
:Polynucleotide 5′-hydroxyl kinase
Description:
Polynucleotide 5′-hydroxyl kinase, identified by the CAS number 37211-65-7, is an enzyme that plays a crucial role in nucleic acid metabolism. This enzyme catalyzes the phosphorylation of the 5′-hydroxyl group of polynucleotides, facilitating the addition of a phosphate group, which is essential for the synthesis of RNA and DNA. The activity of this kinase is vital for various cellular processes, including DNA repair, replication, and transcription. It typically requires ATP as a phosphate donor, and its activity can be influenced by factors such as pH, temperature, and the presence of specific ions or cofactors. The enzyme is of significant interest in molecular biology and biotechnology, particularly in applications involving gene cloning, sequencing, and the development of therapeutic agents. Understanding its characteristics and mechanisms can provide insights into cellular functions and the regulation of genetic information.
Formula:Unspecified
Synonyms:- Polynucleotide 5′-hydroxyl kinase
- Polynucleotide kinase
- DNA 5′-Hydroxyl kinase
- Kinase (phosphorylating), polynucleotide 5′-hydroxyl
- E.C. 2.7.1.78
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Polynucleotide kinase
CAS:Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end<sup></sup>.
