Glucosylceramidase, also known as glucocerebrosidase, is an enzyme that plays a crucial role in the metabolism of glycosphingolipids, specifically in the hydrolysis of glucocerebrosides into glucose and ceramide. This enzyme is primarily found in lysosomes and is essential for the proper degradation of complex lipids. Deficiencies in glucosylceramidase activity can lead to the accumulation of glucocerebrosides, resulting in Gaucher's disease, a genetic disorder characterized by various symptoms, including organ enlargement and skeletal issues. The enzyme operates optimally at a specific pH and temperature, which are critical for its activity. Glucosylceramidase is also of interest in therapeutic contexts, as enzyme replacement therapy is a common treatment for Gaucher's disease. The CAS number 37228-64-1 uniquely identifies this enzyme in chemical databases, facilitating research and development in biochemistry and pharmacology. Overall, glucosylceramidase is a vital enzyme with significant implications for human health and disease management.

Glucosylceramidase

37228-64-1: Glucosylceramidase, also known as glucocerebrosidase, is an enzyme that plays a crucial role in the metabolism of glycosphingolipids, specifically in the hydrolysis of glucocerebrosides into glucose and ceramide. This enzyme is primarily found in lysosomes and is essential for the proper degradation of complex lipids. Deficiencies in glucosylceramidase activity can lead to the accumulation of glucocerebrosides, resulting in Gaucher's disease, a genetic disorder characterized by various symptoms, including organ enlargement and skeletal issues. The enzyme operates optimally at a specific pH and temperature, which are critical for its activity. Glucosylceramidase is also of interest in therapeutic contexts, as enzyme replacement therapy is a common treatment for Gaucher's disease. The CAS number 37228-64-1 uniquely identifies this enzyme in chemical databases, facilitating research and development in biochemistry and pharmacology. Overall, glucosylceramidase is a vital enzyme with significant implications for human health and disease management.

Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose

CAS 37228-64-1

Glucosylceramidase

Glucocerebrosidase

Ref: TM-T78573