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CAS 37231-28-0

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Melittin

Description:
Melittin is a peptide derived from bee venom, specifically from the honeybee (Apis mellifera). It is composed of 26 amino acids and is known for its potent biological activity. Melittin exhibits strong hemolytic properties, meaning it can lyse red blood cells, which is attributed to its ability to disrupt cell membranes. This amphipathic peptide has both hydrophobic and hydrophilic regions, allowing it to interact with lipid bilayers effectively. In addition to its hemolytic activity, melittin has been studied for its potential anti-inflammatory, antimicrobial, and anticancer properties, making it a subject of interest in biomedical research. Its mechanism of action often involves the formation of pores in cell membranes, leading to cell death. Melittin is also known to stimulate the release of various inflammatory mediators, which can contribute to its effects in biological systems. Due to its potent activity, melittin is being explored for therapeutic applications, although its cytotoxicity poses challenges for clinical use.
Formula:Unspecified
InChI:InChI=1/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1
Synonyms:
  • Melitina
  • Melittine
  • Melittin
  • H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
  • Beevenommelittin
  • melittin from bee venom sequencing*grade
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Found 1 products.
  • Melittin Trifluoroacetic Acid Salt (~80%)
    TRC
    + Info

    Melittin Trifluoroacetic Acid Salt (~80%)

    Controlled Product
    CAS:

    Stability Hygroscopic
    Applications MelittinTrifluoroacetic Acid Salt is the Trifluoroacetic Acid Salt version of Melittin which is an apoptosis inducer, a NF-κB inhibitor, and a PLA2 activator.
    References Han, S., et al.: J Asian Nat Prod Res. 11, 796-804 (2009); Park, C., et al.: Biochem. Biophys. Res. Commun., 394, 170-172 (2010); Park, J.H., et al.: Mol. Cells., 29, 209-215 (2010);

    Formula:C131H229N39O31·x(C2HF3O2)
    Purity:~80%
    Color and Shape:Neat
    Molecular weight:2846.5

    Ref: TR-M215493

    1mg
    259.00€
    5mg
    498.00€
    25mg
    850.00€