CAS 37293-17-7

Boanmycin

Description:

Boanmycin, with the CAS number 37293-17-7, is an antibiotic compound that belongs to the class of anthracyclines. It is primarily derived from the fermentation of certain strains of Streptomyces bacteria. Boanmycin exhibits potent antitumor activity, making it a subject of interest in cancer research and chemotherapy. The compound functions by intercalating into DNA, disrupting the replication process, and ultimately leading to cell death. Its chemical structure features a complex polycyclic ring system, which is characteristic of many anthracycline antibiotics. Boanmycin has shown effectiveness against a variety of cancer cell lines in preclinical studies, although its clinical application may be limited due to potential side effects and toxicity. As with many antibiotics, resistance can develop, necessitating ongoing research into its mechanisms and potential combination therapies. Overall, Boanmycin represents a significant area of study in the search for effective cancer treatments, highlighting the importance of natural products in medicinal chemistry.

Formula: C₆₀H₉₆N₂₀O₂₁S₂

InChI: InChI=1S/C60H96N20O21S2/c1-25-38(77-51(80-49(25)64)30(17-36(63)84)72-18-29(62)50(65)90)55(94)79-40(46(31-19-69-24-73-31)99-59-48(44(88)42(86)34(20-81)98-59)100-58-45(89)47(101-60(66)96)43(87)35(21-82)97-58)56(95)74-27(3)41(85)26(2)52(91)78-39(28(4)83)54(93)71-16-9-37-75-33(23-102-37)57-76-32(22-103-57)53(92)70-15-8-14-68-12-6-5-11-67-13-7-10-61/h19,22-24,26-30,34-35,39-48,58-59,67-68,72,81-83,85-89H,5-18,20-21,61-62H2,1-4H3,(H2,63,84)(H2,65,90)(H2,66,96)(H,69,73)(H,70,92)(H,71,93)(H,74,95)(H,78,91)(H,79,94)(H2,64,77,80)/t26-,27+,28+,29-,30-,34-,35+,39-,40-,41-,42+,43+,44-,45-,46-,47-,48-,58+,59-/m0/s1

InChI key: InChIKey=FOUFFVYWFNBHHH-YNGSZULRSA-N

SMILES: [C@H]([C@H](NC(=O)C1=NC([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)=NC(N)=C1C)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC2=NC(=CS2)C3=NC(C(NCCCNCCCCNCCCN)=O)=CS3)=O)[C@@H](C)O)=O)C)O)C)=O)(O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](CO)O4)C6=CN=CN6

Synonyms:

• Bleomycinamide, N1-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-
• Bleomycin A6
• Pingyangmycin A6
• Zhengguangmycin A6
• N1-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]bleomycinamide

Boanmycin

CAS: 37293-17-7

Boanmycin, an antibiotic exhibiting antitumor activity, induces cellular senescence and apoptosis [1] [2] [3].

Formula: C₆₀H₉₆N₂₀O₂₁S₂

Color and Shape: Solid

Molecular weight: 1497.66

Ref: TM-T74590