CAS 37338-80-0

Orellanine

Description:

Orellanine is a toxic compound primarily associated with certain species of mushrooms, particularly those in the Cortinarius genus. It is classified as an alkaloid and is known for its nephrotoxic properties, which can lead to severe kidney damage upon ingestion. Orellanine is typically a colorless to pale yellow crystalline substance, and it is soluble in water and alcohol, which facilitates its absorption in biological systems. The compound is notable for its delayed onset of toxicity, with symptoms often appearing days after consumption, making it particularly dangerous. Its mechanism of action involves the disruption of cellular processes, leading to oxidative stress and apoptosis in renal cells. Due to its toxicity, there is significant interest in understanding its biochemical pathways and potential antidotes. Safety measures are crucial when dealing with mushrooms containing this compound, as even small amounts can pose serious health risks. Overall, orellanine serves as a reminder of the complexities and dangers associated with natural toxins in the environment.

Formula: C₁₀H₈N₂O₆

InChI: InChI=1S/C10H8N2O6/c13-5-1-3-11(17)7(9(5)15)8-10(16)6(14)2-4-12(8)18/h1-4,13-16H

InChI key: InChIKey=JEWWXPOUSBVQKG-UHFFFAOYSA-N

SMILES: OC1=C(N(=O)=CC=C1O)C2=C(O)C(O)=CC=N2=O

Synonyms:

• 2-(3,4-Dihydroxy-1-oxidopyridin-1-ium-2-yl)-3,4-dihydroxypyridin-1-ium-1-olate
• 2-Ethoxyacetaldehyde
• 3,3′,4,4′-Tetrahydroxy-2,2′-bipyridine-1,1′-dioxide
• Acetaldehyde, 2-Ethoxy-
• Ethoxyacetaldehyde
• Orellanine
• [2,2′-Bipyridine]-3,3′,4,4′-tetrol, 1,1′-dioxide

Orellanine

CAS: 37338-80-0

Orellanine

Purity: ≥90%

Molecular weight: 252.18g/mol

Ref: 54-BUP07187

2-(3,4-Dihydroxy-1-oxidopyridin-1-ium-2-yl)-3,4-dihydroxypyridin-1-ium-1-olate

CAS: 37338-80-0

2-(3,4-Dihydroxy-1-oxidopyridin-1-ium-2-yl)-3,4-dihydroxypyridin-1-ium-1-olate

Purity: ≥95%

Color and Shape: White Powder

Molecular weight: 252.18g/mol

Ref: 54-OR307233

2-(3,4-dihydroxy-1-oxidopyridin-1-ium-2-yl)-3,4-dihydroxypyridin-1-ium-1-olate

CAS: 37338-80-0

Formula: C₁₀H₈N₂O₆

Purity: 95%

Molecular weight: 252.182

Ref: 10-F521387

Orellanine

Controlled Product

CAS: 37338-80-0

Formula: C₁₀H₈N₂O₆

Color and Shape: Neat

Molecular weight: 252.18

Ref: TR-O674600

Orellanine

CAS: 37338-80-0

Orellanine is a nephrotoxic compound, which is a naturally occurring toxin found in certain fungi, particularly species in the Cortinarius genus. Its mode of action involves the disruption of renal cellular function, specifically targeting the proximal tubules in the kidneys. This leads to acute renal failure by inducing oxidative stress and apoptosis within kidney cells. The compound’s toxicity is delayed, with symptoms often appearing days to weeks after ingestion, complicating diagnosis and treatment.

Formula: C₁₀H₈N₂O₆

Purity: Min. 95%

Molecular weight: 252.18 g/mol

Ref: 3D-MBA33880

Orellanine

CAS: 37338-80-0

Orellanine, from Cortinarius orellanus, is nephrotoxic and hinders macromolecule synthesis in kidney cells and liver mitochondria.

Formula: C₁₀H₈N₂O₆

Purity: 99.66%

Color and Shape: Solid

Molecular weight: 252.18

Ref: TM-T33817