CAS 37460-15-4

γ-Glutamylhistidine

Description:

γ-Glutamylhistidine is a dipeptide composed of the amino acids glutamic acid and histidine, linked by a peptide bond. It is characterized by its unique structure, which includes a γ-carboxyl group from glutamic acid and an imidazole side chain from histidine, contributing to its biochemical properties. This compound is soluble in water and exhibits a zwitterionic nature at physiological pH, allowing it to participate in various biochemical reactions. γ-Glutamylhistidine plays a role in cellular metabolism and may be involved in the synthesis of other bioactive compounds. It is also of interest in the study of peptide transport mechanisms and potential therapeutic applications due to its involvement in cellular signaling pathways. The CAS number 37460-15-4 uniquely identifies this compound in chemical databases, facilitating research and regulatory processes. Overall, γ-Glutamylhistidine is significant in both biochemical research and potential clinical applications, highlighting the importance of dipeptides in biological systems.

Formula: C₁₁H₁₆N₄O₅

InChI: InChI=1S/C11H16N4O5/c12-7(10(17)18)1-2-9(16)15-8(11(19)20)3-6-4-13-5-14-6/h4-5,7-8H,1-3,12H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/t7-,8-/m0/s1

InChI key: InChIKey=PXVCMZCJAUJLJP-YUMQZZPRSA-N

SMILES: C([C@H](NC(CC[C@@H](C(O)=O)N)=O)C(O)=O)C1=CN=CN1

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Histidine, <smallcap>L</span>-γ-glutamyl-
• <span class="text-smallcaps">L</smallcap>-Histidine, N-<smallcap>L</span>-γ-glutamyl-
• <span class="text-smallcaps">L</smallcap>-γ-Glutamyl-<smallcap>L</span>-histidine
• H-.gamma.-Glu-His-OH
• γ-Glu-His
• γ-Glutamyl-<span class="text-smallcaps">L</span>-histidine
• γ-Glutamylhistidine
• γ-Glutamyl-L-histidine
• L-γ-Glutamyl-L-histidine
• L-Histidine, N-L-γ-glutamyl-
• L-Histidine, L-γ-glutamyl-

H-Glu(His-OH)-OH

CAS: 37460-15-4

Bachem ID: 4014368.

Formula: C₁₁H₁₆N₄O₅

Color and Shape: White Powder

Molecular weight: 284.27

Ref: 01-4014368

H-γ-Glu-His-Oh

Controlled Product

CAS: 37460-15-4

Formula: C₁₁H₁₆N₄O₅

Color and Shape: Neat

Molecular weight: 284.269

Ref: TR-G245145

H-Glu(His-OH)-OH

CAS: 37460-15-4

H-Glu(His-OH)-OH is a protein, which can be found in the plasma samples of patients with fatty acid metabolism disorders. It is one of the most selective markers for identifying these disorders and has been extensively used for profiling and genomic analyses. H-Glu(His-OH)-OH is also present in rat cerebral cortex and it has been shown to be statistically significantly elevated in cerebral cortex samples from patients with Alzheimer's disease. This protein has been observed to have an acidic property and can be used as a biomimetic marker. Regression analysis has shown that H-Glu(His-OH)-OH levels are correlated with the severity of neuronal damage. This protein may serve as a biomarker for different diseases, including Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis (ALS).

Formula: C₁₁H₁₆N₄O₅

Purity: Min. 95%

Molecular weight: 284.27 g/mol

Ref: 3D-FG108266