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CAS 37517-30-9

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Acebutolol

Description:
Acebutolol is a selective beta-1 adrenergic antagonist, primarily used in the treatment of hypertension and certain cardiac conditions. It is classified as a cardioselective beta-blocker, which means it preferentially blocks beta-1 receptors in the heart, leading to decreased heart rate and myocardial contractility. The chemical formula of acebutolol is C18H28N2O4S, and it features a sulfonamide group, which contributes to its pharmacological properties. Acebutolol is known for its relatively mild side effect profile compared to non-selective beta-blockers, making it suitable for patients with respiratory conditions. It is typically administered orally and has a moderate half-life, allowing for once or twice daily dosing. Additionally, acebutolol exhibits intrinsic sympathomimetic activity, which means it can partially stimulate beta receptors while blocking them, providing a unique mechanism of action. Its efficacy and safety profile make it a valuable option in managing cardiovascular diseases, particularly in patients with concomitant conditions.
Formula:C18H28N2O4
InChI:InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
InChI key:InChIKey=GOEMGAFJFRBGGG-UHFFFAOYSA-N
SMILES:O(CC(CNC(C)C)O)C1=C(C(C)=O)C=C(NC(CCC)=O)C=C1
Synonyms:
  • (.+-.)-Acebutolol
  • (RS)-Acebutolol
  • Acecor
  • Acetobutolol
  • Monitan
  • N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide
  • Neptal
  • Prent
  • dl-Acebutolol
  • Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
  • See more synonyms
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