CAS 3761-46-4

2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione

Description:

2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione, also known as indandione, is an organic compound characterized by its unique structure that includes a phenyl group and a hydroxyl group attached to an indene backbone. This compound typically appears as a yellow to orange crystalline solid and is known for its potential applications in organic synthesis and as a dye. It exhibits properties such as moderate solubility in organic solvents and limited solubility in water, which is common for many organic compounds with large aromatic systems. The presence of the hydroxyl group contributes to its reactivity, allowing it to participate in various chemical reactions, including condensation and oxidation. Additionally, 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione can act as a ligand in coordination chemistry, forming complexes with metal ions. Its unique structure and properties make it of interest in fields such as materials science and medicinal chemistry, where it may serve as a precursor for more complex molecules or as a functional material.

Formula: C₁₅H₁₀O₃

InChI: InChI=1S/C15H10O3/c16-13-11-8-4-5-9-12(11)14(17)15(13,18)10-6-2-1-3-7-10/h1-9,18H

InChI key: InChIKey=FZNLKDSIHNSWTM-UHFFFAOYSA-N

SMILES: OC1(C(=O)C=2C(C1=O)=CC=CC2)C3=CC=CC=C3

Synonyms:

• 1H-Indene-1,3(2H)-dione, 2-hydroxy-2-phenyl-
• 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione
• 1,3-Indandione, 2-hydroxy-2-phenyl-
• 2-Hydroxy-2-phenylindan-1,3-dione

Phenindione impurity 1

CAS: 3761-46-4

Phenindione impurity 1

Color and Shape: White

Ref: 47-1209

2-Hydroxy-2-phenyl-d5-1H-indene-1,3(2H)-dione

Controlled Product

CAS: 3761-46-4

Applications 2-Hydroxy-2-phenyl-d5-1H-indene-1,3(2H)-dione is the labeled analogue of 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione (H949575), an impurity of phenindione (P297250), a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
References Haywood, P.A., et. al.: P. Anal. Div. Chem. Soc., 15, 332 (1978); Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010)

Formula: C₁₅H₅D₅O₃

Color and Shape: Neat

Molecular weight: 238.24

Ref: TR-H949577

2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione

Controlled Product

CAS: 3761-46-4

Applications 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione is an impurity of phenindione (P297250), a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
References Haywood, P.A., et. al.: P. Anal. Div. Chem. Soc., 15, 332 (1978); Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010)

Formula: C₁₅H₁₀O₃

Color and Shape: Neat

Molecular weight: 238.24

Ref: TR-H949575