CAS 376348-65-1

Maraviroc

Description:

Maraviroc is a chemokine receptor antagonist primarily used as an antiretroviral medication for the treatment of HIV infection. It specifically targets the CCR5 receptor on the surface of immune cells, preventing the virus from entering and infecting these cells. Maraviroc is characterized by its selective inhibition of CCR5-tropic HIV strains, making it effective in patients whose viral strains utilize this receptor for entry. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other antiretroviral agents. Its mechanism of action involves blocking the interaction between HIV and the CCR5 receptor, thereby reducing viral load and improving immune function. Maraviroc is often used in combination with other antiretroviral drugs to enhance treatment efficacy and is subject to specific resistance patterns, necessitating prior testing for CCR5 tropism before initiation of therapy. As with any medication, monitoring for potential adverse effects and drug interactions is essential during treatment.

Formula: C₂₉H₄₁F₂N₅O

InChI: InChI=1/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1

InChI key: InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N

SMILES: C(C[C@H](NC(=O)C1CCC(F)(F)CC1)C2=CC=CC=C2)N3[C@@]4(C[C@@H](C[C@]3(CC4)[H])N5C(C(C)C)=NN=C5C)[H]

Synonyms:

• 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide
• 4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
• UK 427857
• Maraviroc
• Celsentri
• Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-
• 4,4-difluoro-N-[(1S)-3-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
• 4,4-difluoro-N-[(1S)-3-{3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
• Maraviroc(UK427857)

Cyclohexanecarboxamide,4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-

CAS: 376348-65-1

Formula: C₂₉H₄₁F₂N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.6655

Ref: IN-DA00I7ET

Maraviroc

CAS: 376348-65-1

Maraviroc

Purity: ≥95%

Molecular weight: 513.67g/mol

Ref: 54-BUP15425

4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octan-8-Yl)-1-Phenylpropyl)Cyclohexane-1-Carboxamide

CAS: 376348-65-1

4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octan-8-Yl)-1-Phenylpropyl)Cyclohexane-1-Carboxamide

Purity: 99.5%

Molecular weight: 513.67g/mol

Ref: 54-PC108866

Maraviroc

CAS: 376348-65-1

Formula: C₂₉H₄₁F₂N₅O

Purity: ≥ 97.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 513.67

Ref: 7W-GP7878

Maraviroc

CAS: 376348-65-1

Formula: C₂₉H₄₁F₂N₅O

Color and Shape: White To Off-White Solid

Molecular weight: 513.68

Ref: 4Z-M-581

Maraviroc

CAS: 376348-65-1

Color and Shape: Neat

Ref: 86-MM3904.00

Maraviroc

CAS: 376348-65-1

Formula: C₂₉H₄₁F₂N₅O

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 513.67

Ref: 3B-M3556

Maraviroc

CAS: 376348-65-1

Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.

Formula: C₂₉H₄₁F₂N₅O

Purity: 97.13% - 99.59%

Color and Shape: Brown Solid

Molecular weight: 513.67

Ref: TM-T6016

Maraviroc

Controlled Product

CAS: 376348-65-1

Formula: C₂₉H₄₁F₂N₅O

Color and Shape: White To Off-White

Molecular weight: 513.67

Ref: TR-M193000

Maraviroc

CAS: 376348-65-1

CCR-5 chemokine receptor antagonist; inhibits HIV entry via gp120 protein

Formula: C₂₉H₄₁F₂N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 513.67 g/mol

Ref: 3D-FM25017