CAS 376348-65-1: Maraviroc

Description: Maraviroc is a chemokine receptor antagonist primarily used as an antiretroviral medication for the treatment of HIV infection. It specifically targets the CCR5 receptor on the surface of immune cells, preventing the virus from entering and infecting these cells. Maraviroc is characterized by its selective inhibition of CCR5-tropic HIV strains, making it effective in patients whose viral strains utilize this receptor for entry. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other antiretroviral agents. Its mechanism of action involves blocking the interaction between HIV and the CCR5 receptor, thereby reducing viral load and improving immune function. Maraviroc is often used in combination with other antiretroviral drugs to enhance treatment efficacy and is subject to specific resistance patterns, necessitating prior testing for CCR5 tropism before initiation of therapy. As with any medication, monitoring for potential adverse effects and drug interactions is essential during treatment.

Formula: C₂₉H₄₁F₂N₅O

InChI: InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1

InChI key: InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N

SMILES: O=C(NC(C=1C=CC=CC1)CCN2C3CCC2CC(N4C(=NN=C4C(C)C)C)C3)C5CCC(F)(F)CC5

Synonyms:

• 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide
• 4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
• UK 427857
• Maraviroc
• Celsentri
• Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-
• 4,4-difluoro-N-[(1S)-3-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
• 4,4-difluoro-N-[(1S)-3-{3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide

Cyclohexanecarboxamide,4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 513.6655

Maraviroc

CAS: 376348-65-1

• Purity: 99.9%
• Molecular weight: 513.67g/mol

Maraviroc

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Purity: ≥ 97.0%
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 513.67

4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octan-8-Yl)-1-Phenylpropyl)Cyclohexane-1-Carboxamide

CAS: 376348-65-1

• Purity: 99.5%
• Molecular weight: 513.67g/mol

Maraviroc

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Color and Shape: White To Off-White Solid
• Molecular weight: 513.68

Maraviroc

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Color and Shape: Neat
• Molecular weight: 513.67

Maraviroc

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Purity: >95.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 513.67

Maraviroc

CAS: 376348-65-1

Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s-MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.

• Formula: C₂₉H₄₁F₂N₅O
• Purity: 100% - 99.55%
• Color and Shape: Brown Solid
• Molecular weight: 513.67

Maraviroc

CAS: 376348-65-1

• Formula: C₂₉H₄₁F₂N₅O
• Color and Shape: White To Off-White
• Molecular weight: 513.67

Maraviroc

CAS: 376348-65-1

CCR-5 chemokine receptor antagonist; inhibits HIV entry via gp120 protein

• Formula: C₂₉H₄₁F₂N₅O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 513.67 g/mol