CymitQuimica logo

CAS 376348-65-1

:

Maraviroc

Description:
Maraviroc is a chemokine receptor antagonist primarily used as an antiretroviral medication for the treatment of HIV infection. It specifically targets the CCR5 receptor on the surface of immune cells, preventing the virus from entering and infecting these cells. Maraviroc is characterized by its selective inhibition of CCR5-tropic HIV strains, making it effective in patients whose viral strains utilize this receptor for entry. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other antiretroviral agents. Its mechanism of action involves blocking the interaction between HIV and the CCR5 receptor, thereby reducing viral load and improving immune function. Maraviroc is often used in combination with other antiretroviral drugs to enhance treatment efficacy and is subject to specific resistance patterns, necessitating prior testing for CCR5 tropism before initiation of therapy. As with any medication, monitoring for potential adverse effects and drug interactions is essential during treatment.
Formula:C29H41F2N5O
InChI:InChI=1/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1
InChI key:InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N
SMILES:C(C[C@H](NC(=O)C1CCC(F)(F)CC1)C2=CC=CC=C2)N3[C@@]4(C[C@@H](C[C@]3(CC4)[H])N5C(C(C)C)=NN=C5C)[H]
Synonyms:
  • 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide
  • 4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
  • UK 427857
  • Maraviroc
  • Celsentri
  • Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-
  • 4,4-difluoro-N-[(1S)-3-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
  • 4,4-difluoro-N-[(1S)-3-{3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
  • Maraviroc(UK427857)
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 10 products.