CAS 37636-51-4

Lividomycin B

Description:

Lividomycin B is a natural antibiotic compound that belongs to the class of aminoglycosides. It is produced by the fermentation of specific strains of the bacterium Micromonospora. This compound exhibits antibacterial properties, particularly effective against a range of Gram-positive bacteria. Lividomycin B is characterized by its complex molecular structure, which includes multiple functional groups that contribute to its biological activity. The substance is typically isolated as a white to off-white powder and is soluble in water and various organic solvents, making it suitable for various pharmaceutical applications. Its mechanism of action involves inhibiting protein synthesis in bacteria, which ultimately leads to cell death. Due to its potential therapeutic benefits, Lividomycin B has garnered interest in the field of medicinal chemistry, particularly in the development of new antibiotics to combat resistant bacterial strains. However, like many antibiotics, its use must be carefully managed to prevent the development of resistance.

Formula: C₂₃H₄₅N₅O₁₃

InChI: InChI=1/C23H45N5O13/c24-3-10-15(33)16(34)13(28)22(36-10)40-19-12(5-30)38-23(17(19)35)41-20-14(32)6(25)1-7(26)18(20)39-21-8(27)2-9(31)11(4-29)37-21/h6-23,29-35H,1-5,24-28H2

InChI key: InChIKey=BRSBFYLXCMGALM-UHFFFAOYSA-N

SMILES: O(C1C(OC2C(O)C(OC3OC(CN)C(O)C(O)C3N)C(CO)O2)C(O)C(N)CC1N)C4OC(CO)C(O)CC4N

Synonyms:

• 4'''-Deglycosyllividomycin A
• Lividomycin B
• Quintomycin D
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2,3-dideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
• Antibiotic SF-767D
• D-Streptamine, O-2-amino-2,3-dideoxy-α-D-ribo-hexopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
• 4-O-(2-Amino-2,3-dideoxy-α-D-ribo-hexopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-2-deoxy-D-streptamine
• O-2,6-Diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2,3-dideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• SF-767D

Lividomycin B

CAS: 37636-51-4

Lividomycin B is an aminoglycoside antibiotic with broad-spectrum activity against bacteria and mycobacteria. It does not exhibit cross-resistance with Streptomyces or Penicillium. Additionally, it offers protective effects in mice infected with Staphylococcus aureus and Pseudomonas aeruginosa.

Formula: C₂₃H₄₅N₅O₁₃

Color and Shape: Solid

Molecular weight: 599.629

Ref: TM-TN10575