CAS 376653-43-9: Ceftobiprole medocaril

Description: Ceftobiprole medocaril is a broad-spectrum cephalosporin antibiotic, primarily used for the treatment of bacterial infections, particularly those caused by resistant strains. It is a prodrug, meaning it is converted into its active form, ceftobiprole, in the body. This compound exhibits a unique mechanism of action by binding to penicillin-binding proteins (PBPs), which inhibits bacterial cell wall synthesis, leading to cell lysis and death. Ceftobiprole is effective against a variety of Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Its pharmacokinetic profile allows for effective dosing regimens, and it is typically administered intravenously. The substance is characterized by its stability against certain beta-lactamases, which enhances its efficacy against resistant bacterial strains. Ceftobiprole medocaril has undergone clinical evaluations for conditions such as complicated skin and soft tissue infections and community-acquired pneumonia, demonstrating its potential in treating serious infections where traditional antibiotics may fail.

Formula: C₂₆H₂₆N₈O₁₁S₂

InChI: InChI=1S/C26H26N8O11S2/c1-10-14(45-26(41)44-10)8-43-25(40)32-4-3-13(7-32)33-5-2-11(20(33)36)6-12-9-46-22-16(21(37)34(22)17(12)23(38)39)28-19(35)15(30-42)18-29-24(27)47-31-18/h6,13,16,22,42H,2-5,7-9H2,1H3,(H,28,35)(H,38,39)(H2,27,29,31)/b11-6+,30-15-/t13-,16-,22-/m1/s1

InChI key: InChIKey=HFTSMHTWUFCYMJ-YIOMYIDASA-N

SMILES: O=C(O)C1=C(C=C2C(=O)N(CC2)C3CN(C(=O)OCC=4OC(=O)OC4C)CC3)CSC5N1C(=O)C5NC(=O)C(=NO)C6=NSC(=N6)N

Synonyms:

• (6R,7R)-7-[[(2Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino]-3-[(E)-[(3′R)-1′-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)acetyl]amino]-3-[(E)-[(3′R)-1′-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino]-3-[(E)-[(3′R)-1′-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-8-oxo-, (6R,7R)-
• Bal-5788
• Ceftobiprole medocaril
• Ro-65-5788
• Ro-65-5788/001
• Zeftera

Ceftobiprole medocaril

CAS: 376653-43-9

• Purity: ≥95%
• Molecular weight: 690.66g/mol

Ceftobiprole medocaril

CAS: 376653-43-9

• Formula: C₂₀H₂₂N₈O₆S₂
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 534.57

Ceftobiprole Medocaril

CAS: 376653-43-9

• Formula: C₂₆H₂₆N₈O₁₁S₂
• Molecular weight: 690.66

Ceftobiprole medocaril

CAS: 376653-43-9

Ceftobiprole medocaril: injectable prodrug; its active form fights broad-range infections including MRSA.

• Formula: C₂₆H₂₆N₈O₁₁S₂
• Purity: 95.14%
• Color and Shape: Liquid
• Molecular weight: 690.66

Ceftobiprole Medocaril

CAS: 376653-43-9

• Formula: C₂₆H₂₆N₈O₁₁S₂
• Color and Shape: Neat
• Molecular weight: 690.662

Ceftobiprole medocaril

CAS: 376653-43-9

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• Formula: C₂₆H₂₆N₈O₁₁S₂
• Purity: Min. 95%
• Molecular weight: 690.66 g/mol