CAS 37686-84-3

Terguride

Description:

Terguride is a chemical compound classified as a selective dopamine receptor agonist, primarily targeting the D2 and D3 dopamine receptors. It is known for its potential therapeutic applications in treating conditions such as Parkinson's disease and other movement disorders due to its ability to mimic the action of dopamine in the brain. The compound exhibits a unique pharmacological profile, which allows it to modulate dopaminergic activity effectively. Terguride is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. Its chemical structure includes a piperidine ring, contributing to its receptor-binding properties. Additionally, Terguride has been studied for its effects on prolactin levels, making it relevant in the context of hyperprolactinemia. As with many pharmacological agents, the safety and efficacy of Terguride are subject to ongoing research, and its use should be guided by clinical evidence and regulatory approvals.

Formula: C₂₀H₂₈N₄O

InChI: InChI=1S/C20H28N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,11,14,16,18,21H,4-5,9-10,12H2,1-3H3,(H,22,25)/t14-,16+,18+/m0/s1

InChI key: InChIKey=JOAHPSVPXZTVEP-YXJHDRRASA-N

SMILES: CN1[C@]2([C@@](C=3C=4C(C2)=CNC4C=CC3)(C[C@H](NC(N(CC)CC)=O)C1)[H])[H]

Synonyms:

• (+)-(5R,8S,10R)-Terguride
• 1,1-Diethyl-3-(6-methylergolin-8alpha-yl)urea
• 1,1-Diethyl-3-[(8Alpha)-6-Methylergolin-8-Yl]Urea
• 1-((5R,8S,10R)-6-Methyl-8-ergolinyl)-3,3-diethylurea
• 6-Methyl-8alpha-(diethylcarbamoylamino)ergoline
• 6-Methyl-8α-(diethylcarbamoylamino)ergoline
• 9,10-alpha-Dihydrolisuride
• 9,10α-Dihydrolisuride
• Brn 0766582
• Ergoline, urea deriv.
• Indolo[4,3-fg]quinoline, urea deriv.
• N,N-Diethyl-N'-(D-6-methyl-10alpha-isoergolin-8-yl)urea
• N,N-Diethyl-N′-(<span class="text-smallcaps">D</span>-6-methyl-10α-isoergolin-8-yl)urea
• N,N-Diethyl-N′-[(8α)-6-methylergolin-8-yl]urea
• Tergurid
• Tergurida
• Tergurida [Spanish]
• Terguride [INN]
• Terguridum
• Terguridum [Latin]
• Urea, N,N-diethyl-N'-((8-alpha)-6-methylergolin-8-yl)-
• Urea, N,N-diethyl-N′-[(8α)-6-methylergolin-8-yl]-
• Zk 31224
• trans-Dihydrolisuride
• (+)-Terguride

Terguride

CAS: 37686-84-3

Formula: C₂₀H₂₈N₄O

Molecular weight: 340.46

Ref: 7W-GP1984

trans-Dihydro Lisuride (9,10α-Dihydrolisuride, Terguride)

CAS: 37686-84-3

Formula: C₂₀H₂₈N₄O

Molecular weight: 340.47

Ref: 4Z-L-190002

trans-Dihydro Lisuride

Controlled Product

CAS: 37686-84-3

Applications An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Spealman, R.D.: Pharmacol. Biochem. Behav., 51, 661 (1995); McDougall, S. et al.: Psychopharmacol., 178, 431 (2005); Yamada, Y. et al.: Yakug. Zas., 123, 255 (2003);

Formula: C₂₀H₂₈N₄O

Color and Shape: Off-White To Light Yellow

Molecular weight: 340.46

Ref: TR-D449495

trans-Dihydro Lisuride-d10

Controlled Product

CAS: 37686-84-3

Applications trans-Dihydro Lisuride-d10 is the isotope labelled analog of trans-Dihydro Lisuride (D449495); an ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. Also an anti-hyperprolactinemia agent.
References Spealman, R.D.: Pharmacol. Biochem. Behav., 51, 661 (1995); McDougall, S. et al.: Psychopharmacol., 178, 431 (2005); Yamada, Y. et al.: Yakug. Zas., 123, 255 (2003)

Formula: C₂₀D₁₀H₁₈N₄O

Color and Shape: Off-White To Beige

Molecular weight: 350.524

Ref: TR-D449497

Terguride

CAS: 37686-84-3

Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.

Formula: C₂₀H₂₈N₄O

Color and Shape: Solid

Molecular weight: 340.46

Ref: TM-T71847