CAS 37691-11-5

Antipain

Description:

Antipain, with the CAS number 37691-11-5, is a synthetic peptide that functions primarily as a protease inhibitor. It is derived from the natural product of the bacterium *Streptomyces* and is known for its ability to inhibit various serine and cysteine proteases, making it a valuable tool in biochemical research. Antipain is often utilized in studies involving protein degradation, cell signaling, and apoptosis, as it can help elucidate the roles of proteases in these processes. The substance is typically characterized by its relatively low molecular weight and specific structural features that allow it to bind to proteases effectively. In laboratory settings, Antipain is usually handled as a powder and is soluble in aqueous solutions, which facilitates its application in various experimental protocols. Safety data sheets recommend standard laboratory precautions when handling this compound, as with any chemical substance. Overall, Antipain serves as an important reagent in the study of proteolytic enzymes and their biological implications.

Formula: C₂₇H₄₄N₁₀O₆

InChI: InChI=1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)

InChI key: InChIKey=SDNYTAYICBFYFH-UHFFFAOYSA-N

SMILES: C(C(NC(C(NC(CCCNC(=N)N)C=O)=O)C(C)C)=O)(NC(NC(CC1=CC=CC=C1)C(O)=O)=O)CCCNC(=N)N

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Valinamide, N²-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-<smallcap>L</span>-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-
• Antipain
• Ccris 3605
• L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-
• L-Valinamide, N2-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-
• N²-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-<span class="text-smallcaps">L</smallcap>-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-<smallcap>L</span>-valinamide
• N~2~-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-N~5~-(diaminomethylidene)-L-ornithyl-N-{(2S)-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}-L-valinamide
• N2-(((1-Carboxyphenethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-L-valinamide
• N2-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide

Antipain

CAS: 37691-11-5

A reversible inhibitor of Ser and Cys proteases with an activity spectrum comparable to leupeptin. Antipain inhibited transformation of NIH3T3 cells after transfection with an activated H-ras oncogene (Cox et al.). Vaccari et al. used antipain for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells.

Formula: C₂₇H₄₄N₁₀O₆

Color and Shape: Yellowish Powder

Molecular weight: 604.71

Ref: 01-4030290

Antipain

CAS: 37691-11-5

Formula: C₂₇H₄₄N₁₀O₆

Molecular weight: 604.70

Ref: 7W-GA6508

Antipain

CAS: 37691-11-5

Antipain, from Actinomycetes, blocks proteases and combats MNNG-induced genetic changes.

Formula: C₂₇H₄₄N₁₀O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 604.713

Ref: TM-T14295

Antipain

CAS: 37691-11-5

Antipain is a protease inhibitor, which is derived from microbial sources. It inhibits serine and cysteine proteases through the formation of a reversible covalent complex with the active site of the enzyme. This interaction effectively prevents the proteolytic activity of these enzymes, thereby modulating various biological processes.The primary application of Antipain is in biochemical research where it is utilized to study protease function and regulation. By inhibiting specific proteases, researchers can investigate protein degradation pathways and decipher complex signaling mechanisms. Additionally, Antipain is used experimentally to inhibit protease activity in cell lysates, thereby preserving protein integrity during sample preparation. Its specificity for serine and cysteine proteases makes it a valuable tool for differentiating between proteolytic activities in various biological samples.

Formula: C₂₇H₄₄N₁₀O₆net

Purity: Min. 95%

Molecular weight: 604.7 g/mol

Ref: 3D-IAP-4062

Antipain

CAS: 37691-11-5

Antipain is a proteolytic enzyme that hydrolyzes peptide bonds in proteins. It is a member of the papain family of proteases and has been shown to activate peptides and inhibit ion channels, both of which are important for cell biology research. Antipain, an inhibitor of protein synthesis, is also used as a research tool in cell biology and biochemistry.

Formula: C₂₇H₄₄N₁₀O₆

Purity: Min. 95%

Molecular weight: 604.7 g/mol

Ref: 3D-IAP-4062-V