CAS 37717-21-8

Flurocitabine

Description:

Fluorocytosine, also known as flurocitabine, is a synthetic antifungal agent primarily used in the treatment of fungal infections, particularly those caused by Candida and Cryptococcus species. It is a pyrimidine analog that inhibits fungal DNA and RNA synthesis by interfering with the metabolism of nucleic acids. The compound is characterized by its ability to penetrate fungal cells effectively, where it is converted into its active form, 5-fluorouracil, which disrupts the synthesis of essential nucleotides. Fluorocytosine is typically administered in combination with other antifungal agents to enhance its efficacy and reduce the risk of resistance. Its pharmacokinetics involve renal excretion, necessitating dosage adjustments in patients with impaired kidney function. Common side effects may include gastrointestinal disturbances and hematological toxicity, such as bone marrow suppression. Due to its specific mechanism of action and the potential for resistance development, careful monitoring during treatment is essential. Overall, fluorocytosine remains a valuable tool in the antifungal arsenal, particularly for serious systemic infections.

Formula: C₉H₁₀FN₃O₄

InChI: InChI=1S/C9H10FN3O4/c10-3-1-13-8-6(5(15)4(2-14)16-8)17-9(13)12-7(3)11/h1,4-6,8,11,14-15H,2H2/t4-,5-,6+,8-/m1/s1

InChI key: InChIKey=PAYBYKKERMGTSS-MNCSTQPFSA-N

SMILES: O[C@H]1[C@]2([C@](N3C(O2)=NC(=N)C(F)=C3)(O[C@@H]1CO)[H])[H]

Synonyms:

• (2R,3R,3aS,9aR)-7-Fluoro-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-6H-furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol
• (2R,3R,6Z,9aR)-7-fluoro-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
• 2,2′-Anhydro-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-5-fluorocytosine
• 5-Fluorocyclocytidine
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 7-fluoro-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, (2R,3R,3aS,9aR)-
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 7-fluoro-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, [2R-(2α,3β,3aβ,9aβ)]-
• Fluorocitabine
• 2,2′-Anhydro-1-β-D-arabinofuranosyl-5-fluorocytosine

Flurocitabine

CAS: 37717-21-8

Flurocitabine is a cytotoxic drug that is used in the treatment of cancer. It inhibits the activity of DNA polymerase and topoisomerase II, which are enzymes that maintain the integrity of DNA. Flurocitabine has been shown to be effective against inflammatory diseases, such as inflammatory bowel disease, and infectious diseases, such as HIV. Flurocitabine has also been shown to stimulate estrogen receptor modulators and fatty acid synthesis in vitro. Clinical studies have shown that flurocitabine can be implanted into c57/bl6 mice for slow-release delivery.

Formula: C₉H₁₀FN₃O₄

Purity: Min. 95%

Molecular weight: 243.19 g/mol

Ref: 3D-FF86181

Flurocitabine

CAS: 37717-21-8

Flurocitabine is a therapeutic agent with antineoplastic activity.

Formula: C₉H₁₀FN₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 243.19

Ref: TM-T27342