CAS 37758-47-7

Ganglioside GM1

Description:

Ganglioside GM1 is a complex glycosphingolipid primarily found in the nervous system, particularly in the brain and spinal cord. It is characterized by its structure, which includes a ceramide backbone linked to a carbohydrate moiety containing sialic acid. This unique structure contributes to its role in cell signaling, neuronal development, and synaptic plasticity. GM1 is known to participate in various biological processes, including cell recognition, adhesion, and modulation of neurotransmitter release. It also plays a crucial role in the formation of lipid rafts, which are microdomains in cell membranes that facilitate signal transduction. Additionally, GM1 has been studied for its potential therapeutic applications in neurodegenerative diseases, as it may help protect neurons from damage and promote regeneration. Its CAS number, 37758-47-7, is used for identification in chemical databases and regulatory contexts. Overall, Ganglioside GM1 is an essential component of cellular membranes with significant implications in neuroscience and cell biology.

Formula: Unspecified

Synonyms:

• G_M1
• G_M1-Ganglioside
• GM1
• GM1-Ganglioside
• Ganglioside A2
• Ganglioside A₂
• Ganglioside G4
• Ganglioside G₄
• Ganglioside G_Gtet1
• Ganglioside G_I
• Ganglioside G_M1
• Ganglioside G_M1a
• Ganglioside GGtet1
• Ganglioside GI
• Ganglioside GM1a
• Ganglioside M1
• Ganglioside M₁
• Monosialotetrahexosylganglioside
• Sialosylganglio-N-tetraosylceramide
• Sygen
• GangliosideGI
• Ganglioside GM1

Ganglioside GM1

CAS: 37758-47-7

Formula: C₇₃H₁₃₁N₃O₃₁

Color and Shape: Solid

Molecular weight: 1,546.84

Ref: 3B-G0483

Ganglioside M1 Sodium Salt (GM1-Ganglioside Sodium Salt)

CAS: 37758-47-7

Formula: C₇₃H₁₃₀N₃O₃₁·Na

Color and Shape: White To Off-White Solid

Molecular weight: 1545.85 22.99

Ref: 4Z-G-070001

Ganglioside GM1

CAS: 37758-47-7

Ganglioside GM1

Purity: ≥95%

Molecular weight: 1546.84g/mol

Ref: 54-BUP20081

Monosialoganglioside GM1 (bovine)

CAS: 37758-47-7

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1101

Ganglioside GM1 Sphinganine (bovine)

CAS: 37758-47-7

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1206

GM1-Ganglioside

CAS: 37758-47-7

Purity: ≥ 97%

Color and Shape: White to pale yellow solid

Molecular weight: -

Ref: 7W-GC2176

Ganglioside GM1

CAS: 37758-47-7

Ganglioside GM1 is protective of the central nervous system and is used to study neurologic disorders.

Formula: C₇₃H₁₃₁N₃O₃₁

Color and Shape: Solid

Molecular weight: 1546.841

Ref: TM-T82341

Ganglioside GM1

CAS: 37758-47-7

Ganglioside GM1 has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009), and is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. Ganglioside GM1 is found in epithelial membranes and is a key element for the detection of bacterial toxicity and viral infection. It is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin (LTB) from E.coli, for rotavirus, and simian virus 40. GM1 functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Formula: C₇₃H₁₃₁N₃O₃₁·xNa

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 1,546.82 g/mol

Ref: 3D-OG03918

Ganglioside GM1 Sodium Salt (bovine brain)

Controlled Product

CAS: 37758-47-7

Applications Ganglioside GM1 Sodium Salt (bovine brain) is a specific receptor for cholera toxin.
References Fishman, P.H., et al.: J. Membr. Biol., 69, 85-97 (1982); Vlasova, I., et al.: Zh. Evol. Biokhim. Fiziol., 45, 465-471 (2009);

Formula: C₇₃H₁₃₁N₃O₃₁·xNa

Color and Shape: Neat

Molecular weight: 1546.82

Ref: TR-G235068

Ganglioside-D35 GM1

Controlled Product

CAS: 37758-47-7

Formula: C₇₃D₃₅H₉₆N₃O₃₁

Color and Shape: Neat

Molecular weight: 1582.038

Ref: TR-G868800