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CAS 3776-38-3

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Streptothricin E

Description:
Streptothricin E is an antibiotic compound that belongs to the class of aminoglycosides, primarily produced by the bacterium *Streptomyces griseus*. It exhibits broad-spectrum antibacterial activity, particularly against Gram-negative bacteria, making it valuable in clinical settings. The compound functions by inhibiting protein synthesis, binding to the bacterial ribosome and disrupting the translation process. Streptothricin E is characterized by its complex structure, which includes multiple amino sugar moieties and a unique cyclic structure that contributes to its biological activity. It is typically administered in a clinical context to treat infections caused by susceptible bacterial strains. However, like many antibiotics, its use is accompanied by concerns regarding resistance development, necessitating careful consideration in therapeutic applications. Additionally, the compound's stability, solubility, and pharmacokinetic properties are important factors influencing its efficacy and safety profile. Overall, Streptothricin E represents a significant tool in the fight against bacterial infections, although its use must be managed judiciously to preserve its effectiveness.
Formula:C25H46N10O9
InChI:InChI=1S/C25H46N10O9/c26-5-1-3-11(27)7-15(38)30-6-2-4-12(28)8-16(39)32-19-20(40)21(44-24(29)42)14(10-36)43-23(19)35-25-33-17-13(37)9-31-22(41)18(17)34-25/h11-14,17-21,23,36-37,40H,1-10,26-28H2,(H2,29,42)(H,30,38)(H,31,41)(H,32,39)(H2,33,34,35)/t11-,12-,13+,14+,17+,18-,19+,20-,21-,23+/m0/s1
InChI key:InChIKey=SCHKAKNJXBPJHD-SNQQVPMJSA-N
SMILES:N([C@H]1[C@H](NC(C[C@H](CCCNC(C[C@H](CCCN)N)=O)N)=O)[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O1)C=2N[C@]3([C@](N2)(C(=O)NC[C@H]3O)[H])[H]
Synonyms:
  • 4H-Imidazo[4,5-c]pyridin-4-one, 2-[[4-O-(aminocarbonyl)-2-[[(3S)-3-amino-6-[[(3S)-3,6-diamino-1-oxohexyl]amino]-1-oxohexyl]amino]-2-deoxy-β-D-gulopyranosyl]amino]-1,3a,5,6,7,7a-hexahydro-7-hydroxy-, (3aS,7R,7aS)-
  • Streptolin
  • 4H-Imidazo[4,5-c]pyridin-4-one, 2-[[2-[3-amino-6-(3,6-diaminohexanamido)hexanamido]-2-deoxy-β-D-gulopyranosyl]amino]-3,3a,5,6,7,7a-hexahydro-7-hydroxy-, 6′-carbamate
  • Streptothricin E
  • 4H-Imidazo[4,5-c]pyridin-4-one, 2-[[4-O-(aminocarbonyl)-2-[[3-amino-6-[(3,6-diamino-1-oxohexyl)amino]-1-oxohexyl]amino]-2-deoxy-β-D-gulopyranosyl]amino]-1,3a,5,6,7,7a-hexahydro-7-hydroxy-, [3aS-[2[R*(R*)],3aα,7α,7aβ]]-
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