CAS 377727-87-2

Preladenant

Description:

Preladenant is a chemical compound that functions primarily as an adenosine A2A receptor antagonist. It has garnered interest in the field of pharmacology, particularly for its potential therapeutic applications in treating conditions such as Parkinson's disease and other neurological disorders. The compound is characterized by its ability to selectively inhibit the A2A receptor, which plays a significant role in modulating neurotransmitter release and influencing motor control. Preladenant's chemical structure includes specific functional groups that contribute to its binding affinity and selectivity for the A2A receptor. In terms of pharmacokinetics, it exhibits properties that allow for oral bioavailability, making it a candidate for convenient administration. Additionally, preclinical studies have indicated that it may help alleviate motor symptoms associated with dopamine deficiency. However, as with many investigational drugs, further clinical trials are necessary to fully understand its efficacy, safety profile, and potential side effects in humans.

Formula: C₂₅H₂₉N₉O₃

InChI: InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)

InChI key: InChIKey=DTYWJKSSUANMHD-UHFFFAOYSA-N

SMILES: NC=1N2C(C3=C(N(CCN4CCN(CC4)C5=CC=C(OCCOC)C=C5)N=C3)N1)=NC(=N2)C6=CC=CO6

Synonyms:

• 2-(2-Furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
• 7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-
• Sch 420814
• Preladenant
• Preladenant (SCH 420814)
• 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1
• MK 3814
• SCH420814; SCH-420814; SCH 420814; MK-3814; MK 3814; MK3814; PRELADENANT
• Sch 420814 Preladenant
• 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1,2,4
• CS-672
• MK-3814
• Preladent
• 5-Amino-2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
• Unii-950o97nupo
• 2-Furan-2-yl-7-(2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethyl)-7,9a-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-ylaMine
• SCH-420814;?SCH 420814;?SCH420814
• MK3814

Preladenant

CAS: 377727-87-2

Formula: C₂₅H₂₉N₉O₃

Purity: %

Color and Shape: Solid

Molecular weight: 503.5563

Ref: IN-DA0077XI

2-(Furan-2-Yl)-7-(2-(4-(4-(2-Methoxyethoxy)Phenyl)Piperazin-1-Yl)Ethyl)-7H-Pyrazolo[4,3-E][1,2,4]Triazolo[1,5-C]Pyrimidin-5-Amine

CAS: 377727-87-2

2-(Furan-2-Yl)-7-(2-(4-(4-(2-Methoxyethoxy)Phenyl)Piperazin-1-Yl)Ethyl)-7H-Pyrazolo[4,3-E][1,2,4]Triazolo[1,5-C]Pyrimidin-5-Amine

Purity: 98+%

Molecular weight: 503.56g/mol

Ref: 54-OR1024390

Preladenant

CAS: 377727-87-2

Preladenant

Purity: ≥95%

Molecular weight: 503.56g/mol

Ref: 54-BUP09999

Preladenant

CAS: 377727-87-2

Preladenant (SCH-420814) is an orally bioavailable antagonist of the adenosine A2A receptor (Ki: 1.1 nM) and has >1000-fold selectivity over all other adenosine

Formula: C₂₅H₂₉N₉O₃

Purity: 98.02% - 99.68%

Color and Shape: Solid

Molecular weight: 503.56

Ref: TM-T4290

Preladenant

Controlled Product

CAS: 377727-87-2

Formula: C₂₅H₂₉N₉O₃

Color and Shape: Neat

Molecular weight: 503.556

Ref: TR-P712600

Preladenant

CAS: 377727-87-2

A2A adenosine receptor antagonist

Formula: C₂₅H₂₉N₉O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 503.56 g/mol

Ref: 3D-FP27156