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CAS 37805-95-1

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2′-Deoxy-5-methoxyuridine

Description:
2′-Deoxy-5-methoxyuridine is a nucleoside analog that is structurally related to uridine, featuring a methoxy group at the 5-position of the pyrimidine ring and lacking the hydroxyl group at the 2′ position of the ribose sugar. This modification enhances its stability and can influence its biological activity. The compound is typically white to off-white in appearance and is soluble in water and organic solvents, making it suitable for various biochemical applications. It is primarily studied for its potential roles in antiviral and anticancer therapies, as it can interfere with nucleic acid synthesis. The presence of the methoxy group may also affect its interaction with nucleic acid polymerases and other enzymes involved in nucleic acid metabolism. As a research chemical, 2′-Deoxy-5-methoxyuridine is of interest in the fields of molecular biology and medicinal chemistry, where it may serve as a tool for studying nucleoside metabolism and the development of therapeutic agents.
Formula:C10H14N2O6
InChI:InChI=1S/C10H14N2O6/c1-17-6-3-12(10(16)11-9(6)15)8-2-5(14)7(4-13)18-8/h3,5,7-8,13-14H,2,4H2,1H3,(H,11,15,16)/t5-,7+,8+/m0/s1
InChI key:InChIKey=XSSHSCHXEASHQU-UIISKDMLSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(OC)C(=O)N1
Synonyms:
  • 2′-Deoxy-5-methoxyuridine
  • Uridine, 2′-deoxy-5-methoxy-
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