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CAS 378746-64-6

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Nemonoxacin

Description:
Nemonoxacin is a synthetic antibiotic belonging to the class of non-fluorinated quinolones. It is primarily characterized by its broad-spectrum antibacterial activity, particularly against Gram-positive bacteria, including strains resistant to traditional antibiotics. Nemonoxacin functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription. This mechanism of action makes it effective against various pathogens, including those responsible for respiratory and skin infections. The compound exhibits favorable pharmacokinetic properties, such as good oral bioavailability and tissue penetration. Additionally, Nemonoxacin has shown efficacy against certain resistant strains, making it a candidate for treating infections where conventional treatments may fail. Its safety profile is still under investigation, but it has been evaluated in clinical trials for various indications. Overall, Nemonoxacin represents a promising addition to the antibiotic arsenal, particularly in the face of rising antibiotic resistance.
Formula:C20H25N3O4
InChI:InChI=1S/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
InChI key:InChIKey=AVPQPGFLVZTJOR-RYUDHWBXSA-N
SMILES:O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC=C1N3C[C@@H](C)C[C@H](N)C3)C4CC4
Synonyms:
  • 3-Quinolinecarboxylic acid, 7-[(3S,5S)-3-amino-5-methyl-1-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-
  • 7-[(3S,5S)-3-Amino-5-methyl-1-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
  • Nemonoxacin
  • Tg-873870
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