CAS 379231-04-6: Saracatinib

Description: Saracatinib, with the CAS number 379231-04-6, is a small molecule inhibitor primarily known for its role as a selective inhibitor of the Src family of kinases. It is characterized by its ability to interfere with cellular signaling pathways that are often dysregulated in various cancers, making it a subject of interest in cancer research and therapy. Saracatinib has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its biological activity. The compound is typically administered orally and has been investigated in clinical trials for its efficacy in treating solid tumors and hematological malignancies. Its pharmacokinetic properties include moderate absorption and metabolism, with a focus on its safety profile and potential side effects. As a targeted therapy, Saracatinib exemplifies the trend towards personalized medicine in oncology, aiming to improve treatment outcomes by specifically inhibiting pathways critical for tumor growth and survival.

Formula: C₂₇H₃₂ClN₅O₅

InChI: InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31)

InChI key: InChIKey=OUKYUETWWIPKQR-UHFFFAOYSA-N

SMILES: ClC1=CC=C2OCOC2=C1NC3=NC=NC4=CC(OCCN5CCN(C)CC5)=CC(OC6CCOCC6)=C43

Synonyms:

• 4-(6-Chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline
• 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-
• 7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-methylenedioxyphenyl]amino]quinazoline
• Azd 0530
• Azd 530
• Azd0530
• N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
• N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

CAS: 379231-04-6

• Formula: C₂₇H₃₂ClN₅O₅
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 542.0265

Saracatinib

CAS: 379231-04-6

• Molecular weight: 542.03g/mol

Saracatinib

CAS: 379231-04-6

• Formula: C₂₇H₃₂ClN₅O₅
• Molecular weight: 542.03

Saracatinib

CAS: 379231-04-6

• Formula: C₂₇H₃₂ClN₅O₅
• Purity: >95.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 542.03

Saracatinib

CAS: 379231-04-6

Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, …

• Formula: C₂₇H₃₂ClN₅O₅
• Purity: 98% - 99.63%
• Color and Shape: Solid
• Molecular weight: 542.03

Saracatinib

CAS: 379231-04-6

Inhibitor of Src and Abl tyrosine kinases; anti-proliferative; anti-migratory

• Formula: C₂₇H₃₂ClN₅O₅
• Purity: Min. 95%
• Molecular weight: 542.03 g/mol

Saracatinib

CAS: 379231-04-6

Applications An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related …

• Formula: C₂₇H₃₂ClN₅O₅
• Color and Shape: Neat
• Molecular weight: 542.03