CAS 379270-37-8: Tenofovir alafenamide
Description:Tenofovir alafenamide (TAF) is an antiretroviral medication primarily used in the treatment of HIV and chronic hepatitis B infections. It is a prodrug of tenofovir, which means it is metabolized in the body to its active form. TAF is characterized by its improved pharmacokinetic profile compared to its predecessor, tenofovir disoproxil fumarate (TDF), allowing for lower dosing and reduced renal and bone toxicity. The chemical structure of TAF includes a phosphonate group, which is crucial for its antiviral activity, and it is typically administered in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. TAF is well-absorbed orally and has a favorable distribution in lymphoid tissues, which is beneficial for targeting HIV reservoirs. Its safety profile is generally favorable, with common side effects including gastrointestinal disturbances. Overall, TAF represents a significant advancement in HIV therapy, providing effective viral suppression with a more manageable side effect profile.
Formula:C21H29N6O5P
InChI:InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
InChI key:InChIKey=LDEKQSIMHVQZJK-CAQYMETFSA-N
SMILES:O=C(OC(C)C)C(NP(=O)(OC=1C=CC=CC1)COC(C)CN2C=NC=3C(=NC=NC32)N)C
- Synonyms:
- <span class="text-smallcaps">L</span>-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
- Gs-7340
- Tenofovir Alafenamide
- Tenofovir Alafenamide free base
- Vemlidy
- L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
- 4: PN: WO2016077321 SEQID: 4 claimed sequence
