CAS 379270-37-8
:Tenofovir alafenamide
Description:
Tenofovir alafenamide (TAF) is an antiretroviral medication primarily used in the treatment of HIV and chronic hepatitis B infections. It is a prodrug of tenofovir, which means it is metabolized in the body to its active form. TAF is characterized by its improved pharmacokinetic profile compared to its predecessor, tenofovir disoproxil fumarate (TDF), allowing for lower dosing and reduced renal and bone toxicity. The chemical structure of TAF includes a phosphonate group, which is crucial for its antiviral activity, and it is typically administered in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. TAF is well-absorbed orally and has a favorable distribution in lymphoid tissues, which is beneficial for targeting HIV reservoirs. Its safety profile is generally favorable, with common side effects including gastrointestinal disturbances. Overall, TAF represents a significant advancement in HIV therapy, providing effective viral suppression with a more manageable side effect profile.
Formula:C21H29N6O5P
InChI:InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
InChI key:InChIKey=LDEKQSIMHVQZJK-CAQYMETFSA-N
SMILES:C([C@H](OCP(OC1=CC=CC=C1)(N[C@H](C(OC(C)C)=O)C)=O)C)N2C=3C(N=C2)=C(N)N=CN3
Synonyms:- <span class="text-smallcaps">L</span>-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
- Gs-7340
- Tenofovir Alafenamide
- Tenofovir Alafenamide free base
- Vemlidy
- L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
- 4: PN: WO2016077321 SEQID: 4 claimed sequence
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
GS-7340
CAS:Formula:C21H29N6O5PPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:476.47Tenofovir alafenamide
CAS:Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.Formula:C21H29N6O5PPurity:99.68% - 99.81%Color and Shape:SolidMolecular weight:476.47Tenofovir Alafenamide-d5 Fumarate(diastereomers)
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications Tenofovir Alafenamide-d5 Fumarate (diastereomers), is labeled GS 7171. Tenofovir Alafenamide (T018555) is an isomer of GS 7171.<br></p>Formula:C21H24D5N6O5P·C4H4O4Color and Shape:NeatMolecular weight:481.5011607Tenofovir Alafenamide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Tenofovir Alafenamide is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C21H29N6O5PColor and Shape:NeatMolecular weight:476.47Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
CAS:Purity:98%Molecular weight:476.473999Tenofovir Alafenamide (100mg/mL in Methanol)
CAS:Controlled ProductFormula:C21H29N6O5PColor and Shape:Colourless To Light YellowMolecular weight:476.47Tenofovir Alafenamide-d7 Fumarate
CAS:Controlled ProductFormula:C21H22D7N6O5P•C4H4O4Color and Shape:NeatMolecular weight:483.51 + 116.07Tenofovir alafenamide (free base)
CAS:<p>Tenofovir alafenamide (free base) is a prodrug of tenofovir with action on viral reverse transcriptase to block replication and is used for treating HIV/AIDS and chronic hepatitis B with improved safety profile.</p>Formula:C21H29N6O5PPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:476.47 g/mol
