CAS 3800-86-0

Dexamethasone hemisuccinate

Description:

Dexamethasone hemisuccinate is a synthetic derivative of dexamethasone, a potent glucocorticoid used primarily for its anti-inflammatory and immunosuppressive properties. This compound is characterized by the presence of a hemisuccinate moiety, which enhances its solubility and bioavailability compared to its parent compound. It typically appears as a white to off-white powder and is soluble in water, making it suitable for parenteral administration. The molecular structure includes a steroid backbone with specific functional groups that contribute to its pharmacological activity. Dexamethasone hemisuccinate is often utilized in clinical settings for the treatment of various conditions, including allergies, autoimmune disorders, and certain types of cancer. Its mechanism of action involves the modulation of gene expression, leading to reduced inflammation and immune response. As with other corticosteroids, it may have side effects, including potential impacts on metabolism, immune function, and electrolyte balance, necessitating careful monitoring during therapeutic use.

Formula: C₂₆H₃₃FO₈

InChI: InChI=1/C26H33FO8/c1-14-10-18-17-5-4-15-11-16(28)8-9-23(15,2)25(17,27)19(29)12-24(18,3)26(14,34)20(30)13-35-22(33)7-6-21(31)32/h8-9,11,14,17-19,29,34H,4-7,10,12-13H2,1-3H3,(H,31,32)/t14-,17+,18+,19+,23+,24+,25+,26+/m1/s1

InChI key: InChIKey=IEKLVCVEJCEIJD-LYRWTKHRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@](F)([C@@H](O)C1)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])(C[C@@H](C)[C@@]2(C(COC(CCC(O)=O)=O)=O)O)[H]

Synonyms:

• (11β,16α)-21-(3-Carboxy-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(hydrogen succinate)
• Dexamethasone 21-hemisuccinate
• Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-
• Dexamethasone hemisuccinate
• (11beta,16alpha)-21-(3-Carboxy-1-oxopropoxy)-9-fluoro-11,17-dihydroxy- 16-methylpregna-1,4-diene-3,20-dione
• 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE 21-HEMISUCCINATE
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE
• DEXAMETHASONE HEMISUCCINATE : BSA
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE : BSA

(11β,16α)-21-(3-Carboxy-1-oxopropoxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

CAS: 3800-86-0

Formula: C₂₆H₃₃FO₈

Color and Shape: Solid

Molecular weight: 492.5338

Ref: IN-DA003ARH

Dexamethasone Hemisuccinate

CAS: 3800-86-0

Applications Dexamethasone Hemisuccinate is a derivative of Dexamethasone (D298800); a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Formula: C₂₆H₃₃FO₈

Color and Shape: Neat

Molecular weight: 492.53

Ref: TR-D298855

Dexamethasone Hemisuccinate-d4

Controlled Product

CAS: 3800-86-0

Applications Dexamethasone Hemisuccinate-d4 is the isotope labelled analog of Dexamethasone Hemisuccinate (D298855); a derivative of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Formula: C₂₆D₄H₂₉FO₈

Color and Shape: Neat

Molecular weight: 496.56

Ref: TR-D298857

(11B,16A)-21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,17-Dihydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione

Controlled Product

CAS: 3800-86-0

(11B,16A)-21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,17-Dihydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione is a synthetic compound that has been shown to have tumorigenic properties in rodents. This compound is an amphipathic molecule with a hydrophobic tail and a hydrophilic head. The hydrophilic head of this molecule interacts with the surface of cancer cells and then induces the release of proinflammatory cytokines. The hydrophobic tail allows it to penetrate into the cell membrane. (11B,16A)-21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,17-Dihydroxy -16 Methyl Pregna 1,4 Diene 3,20 Dione can be conjugated to chemotherape

Formula: C₂₆H₃₃FO₈

Purity: Min. 95%

Molecular weight: 492.53 g/mol

Ref: 3D-FC102424